TY - JOUR
T1 - Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot
AU - Milcovich, Gesmi
AU - Lettieri, Stefania
AU - Antunes, Filipe E.
AU - Medronho, Bruno
AU - Fonseca, Ana C.
AU - Coelho, Jorge F.J.
AU - Marizza, Paolo
AU - Perrone, Francesca
AU - Farra, Rossella
AU - Dapas, Barbara
AU - Grassi, Gabriele
AU - Grassi, Mario
AU - Giordani, Silvia
PY - 2017
Y1 - 2017
N2 - Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications.In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
AB - Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehensive understanding of the processes involved in the self-assembly of the colloidal structures discussed therein is essential for the development of relevant biomedical applications.In this review we report the most promising and best performing platforms for specific classes of bioactive molecules and related target, spanning from siRNAs, gene/plasmids, proteins/growth factors, small synthetic therapeutics and bioimaging probes.
KW - Bioactive molecule delivery
KW - Carbon nano materials
KW - Hydrogels
KW - Liposomes
KW - Micro/nanocarriers
U2 - 10.1016/j.cis.2017.05.009
DO - 10.1016/j.cis.2017.05.009
M3 - Journal article
C2 - 28527520
SN - 0001-8686
VL - 249
SP - 163
EP - 180
JO - Advances in Colloid and Interface Science
JF - Advances in Colloid and Interface Science
ER -