Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering

Changhee Cho, So Young Choi, Zi Wei Luo, Sang Yup Lee

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The advent of various systems metabolic engineering tools and strategies has enabled more sophisticated engineering of microorganisms for the production of industrially useful fuels and chemicals. Advances in systems metabolic engineering have been made in overproducing natural chemicals and producing novel non-natural chemicals. In this paper, we review the tools and strategies of systems metabolic engineering employed for the development of microorganisms for the production of various industrially useful chemicals belonging to fuels, building block chemicals, and specialty chemicals, in particular focusing on those reported in the last three years. It was aimed at providing the current landscape of systems metabolic engineering and suggesting directions to address future challenges towards successfully establishing processes for the bio-based production of fuels and chemicals from renewable resources.
Original languageEnglish
JournalBiotechnology Advances
Volume33
Issue number7
Pages (from-to)1455-1466
Number of pages12
ISSN0734-9750
DOIs
Publication statusPublished - 2015

Keywords

  • Systems metabolic engineering
  • Fuels
  • Building block chemicals
  • Specialty chemicals

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