Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles

María José York-Durán, Maria Godoy Gallardo, Cédric Pierre Labay, Andrew Urquhart, Thomas Lars Andresen, Leticia Hosta-Rigau

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Compartmentalization is a key feature of biological cells which conduct their metabolic activity in individual steps isolated in distinct, separated compartments. The creation of architectures containing multiple compartments with a structure that resembles that of a biological cell has generated significant research attention and these assemblies are proposed as candidate materials for a range of biomedical applications. In this Review article, the recent successes of multicompartment architectures as carriers for the delivery of therapeutic cargo or the creation of micro- and nanoreactors that mimic metabolic activities, thus acting as artificial cells or organelles, are discussed. The developed technologies to assemble such complex architectures are outlined, the multicompartment carriers' properties which contribute to their performance in diverse applications are discussed, and their successful applications are highlighted. Finally, future directions and developments in the field are suggested.
    Original languageEnglish
    JournalColloids and Surfaces B: Biointerfaces
    Volume152
    Pages (from-to)199-213
    Number of pages15
    ISSN0927-7765
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Artificial cells
    • Cell mimicry
    • Encapsulated enzymatic reactions
    • Microreactors
    • Multi-compartment carriers

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