Recent Advances and Challenges towards Sustainable Polyhydroxyalkanoate (PHA) Production

Constantina Kourmentza, Jersson Plácido, Nikolaos Venetsaneas, Anna Burniol Figols, Cristiano Varrone, Hariklia N. Gavala, Maria A. M. Rei

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Sustainable biofuels, biomaterials, and fine chemicals production is a critical matter that research teams around the globe are focusing on nowadays. Polyhydroxyalkanoates represent one of the biomaterials of the future due to their physicochemical properties, biodegradability, and biocompatibility. Designing efficient and economic bioprocesses, combined with the respective social and environmental benefits, has brought together scientists from different backgrounds highlighting the multidisciplinary character of such a venture. In the current review, challenges and opportunities regarding polyhydroxyalkanoate production are presented and discussed, covering key steps of their overall production process by applying pure and mixed culture biotechnology, from raw bioprocess development to downstream processing.
Original languageEnglish
Article number55
JournalJournal of Bioscience and Bioengineering
Issue number2
Number of pages43
Publication statusPublished - 2017


  • Polyhydroxyalkanoates
  • Biopolymers
  • Renewable feedstock
  • Mixed microbial consortia
  • Enrichment strategy
  • Pure cultures
  • Synthetic biology
  • Downstream processing

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