Real-time monitoring of cellular dynamics using a microfluidic cell culture system with integrated electrode array and potentiostat

Kinga Zor, M. Vergani, Arto Heiskanen, E. Landini, M. Carminati, V. Coman, Indumathi Vedarethinam, Peder Skafte-Pedersen, Maciej Skolimowski, A. Martinez Serrano, M. Kokaia, T. Ramos Moreno, A. Ghio, Winnie Edith Svendsen, Maria Dimaki, Zs. Keresztes, M. Adamovski, U. Wollenberger, David Sabourin, G. FerrariR. Raiteri, M. Sampietro, Martin Dufva, Jenny Emnéus

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    Abstract

    A versatile microfluidic, multichamber cell culture and analysis system with an integrated electrode array and potentiostat suitable for electrochemical detection and microscopic imaging is presented in this paper. The system, which allows on-line electrode cleaning and modification, was developed for real-time monitoring of cellular dynamics, exemplified in this work by monitoring of redox metabolism inside living yeast cells and dopamine release from PC12 cells.
    Original languageEnglish
    Title of host publicationProceedings of International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Publication date2011
    Publication statusPublished - 2011
    Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Seattle, WA, United States
    Duration: 2 Oct 20116 Oct 2011
    http://www.microtas2011.org/

    Conference

    Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Country/TerritoryUnited States
    CitySeattle, WA
    Period02/10/201106/10/2011
    Internet address

    Keywords

    • Cellular Dynamics Monitoring
    • On-line Measurement
    • Dopamine Exocytosis
    • Microfluidic Cell Culture System

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