Reactivity of eleven anti-human leucocyte monoclonal antibodies with lymphocytes from several domestic animals

Bent Aasted; Merete Blixenkrone-Møller; Else Bang Larsen; Helle Ohmann Bielefeldt; Ruth Buemann Simensen; Åse Uttenthal

doi:10.1016/0165-2427(88)90044-X

Reactivity of eleven anti-human leucocyte monoclonal antibodies with lymphocytes from several domestic animals

Bent Aasted, Merete Blixenkrone-Møller, Else Bang Larsen, Helle Ohmann Bielefeldt, Ruth Buemann Simensen, Åse Uttenthal

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Abstract

Nine commercially available monoclonal antibodies and two monoclonal antibodies from The American Type Culture Collection, raised against various human leucocyte surface antigens, were tested on lymphocytes from cow, sheep, goat, swine, horse, cat, dog, mink, and rabbit as well as man. Four antibodies bound to lymphocytes from some of the animals. These were the antibodies against CD8 and CD4 antigen, the antibody to C3b-receptor, and the antibody to the HLA-DR antigen. The CD8 antigen-reactive antibody reacted with lymphocytes from mink, cat, dog, and sheep, while the CD4 antigen-reactive antibody reacted with lymphocytes from mink. The anti-C3b-R antibody reacted with lymphocytes from horse, swine, dog, and cat, and the anti-HLA-DR reacted with lymphocytes from cow, goat, sheep, horse, dog, cat, and mink.

Original language	English
Journal	Veterinary Immunology and Immunopathology
Volume	19
Issue number	1
Pages (from-to)	31-38
DOIs	https://doi.org/10.1016/0165-2427(88)90044-X
Publication status	Published - 1988

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title = "Reactivity of eleven anti-human leucocyte monoclonal antibodies with lymphocytes from several domestic animals",

abstract = "Nine commercially available monoclonal antibodies and two monoclonal antibodies from The American Type Culture Collection, raised against various human leucocyte surface antigens, were tested on lymphocytes from cow, sheep, goat, swine, horse, cat, dog, mink, and rabbit as well as man. Four antibodies bound to lymphocytes from some of the animals. These were the antibodies against CD8 and CD4 antigen, the antibody to C3b-receptor, and the antibody to the HLA-DR antigen. The CD8 antigen-reactive antibody reacted with lymphocytes from mink, cat, dog, and sheep, while the CD4 antigen-reactive antibody reacted with lymphocytes from mink. The anti-C3b-R antibody reacted with lymphocytes from horse, swine, dog, and cat, and the anti-HLA-DR reacted with lymphocytes from cow, goat, sheep, horse, dog, cat, and mink.",

author = "Bent Aasted and Merete Blixenkrone-M{\o}ller and Larsen, {Else Bang} and Bielefeldt, {Helle Ohmann} and Simensen, {Ruth Buemann} and {\AA}se Uttenthal",

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doi = "10.1016/0165-2427(88)90044-X",

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T1 - Reactivity of eleven anti-human leucocyte monoclonal antibodies with lymphocytes from several domestic animals

AU - Aasted, Bent

AU - Blixenkrone-Møller, Merete

AU - Larsen, Else Bang

AU - Bielefeldt, Helle Ohmann

AU - Simensen, Ruth Buemann

AU - Uttenthal, Åse

PY - 1988

Y1 - 1988

N2 - Nine commercially available monoclonal antibodies and two monoclonal antibodies from The American Type Culture Collection, raised against various human leucocyte surface antigens, were tested on lymphocytes from cow, sheep, goat, swine, horse, cat, dog, mink, and rabbit as well as man. Four antibodies bound to lymphocytes from some of the animals. These were the antibodies against CD8 and CD4 antigen, the antibody to C3b-receptor, and the antibody to the HLA-DR antigen. The CD8 antigen-reactive antibody reacted with lymphocytes from mink, cat, dog, and sheep, while the CD4 antigen-reactive antibody reacted with lymphocytes from mink. The anti-C3b-R antibody reacted with lymphocytes from horse, swine, dog, and cat, and the anti-HLA-DR reacted with lymphocytes from cow, goat, sheep, horse, dog, cat, and mink.

AB - Nine commercially available monoclonal antibodies and two monoclonal antibodies from The American Type Culture Collection, raised against various human leucocyte surface antigens, were tested on lymphocytes from cow, sheep, goat, swine, horse, cat, dog, mink, and rabbit as well as man. Four antibodies bound to lymphocytes from some of the animals. These were the antibodies against CD8 and CD4 antigen, the antibody to C3b-receptor, and the antibody to the HLA-DR antigen. The CD8 antigen-reactive antibody reacted with lymphocytes from mink, cat, dog, and sheep, while the CD4 antigen-reactive antibody reacted with lymphocytes from mink. The anti-C3b-R antibody reacted with lymphocytes from horse, swine, dog, and cat, and the anti-HLA-DR reacted with lymphocytes from cow, goat, sheep, horse, dog, cat, and mink.

U2 - 10.1016/0165-2427(88)90044-X

DO - 10.1016/0165-2427(88)90044-X

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JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

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ER -

Reactivity of eleven anti-human leucocyte monoclonal antibodies with lymphocytes from several domestic animals

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