Reactive oxygen species and their detoxification in healing skin wounds

Ulrich Auf Dem Keller, Angelika Kümin, Susanne Braun, Sabine Werner*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Injury to the skin initiates a cascade of events, which finally lead to at least partial reconstruction of the wounded tissue. The wound-healing process has been well described at the histological level, but the underlying molecular mechanisms are still poorly defined. To gain insight into these mechanisms we searched for genes, which are regulated by skin injury. Interestingly, some of the genes that we identified encode cytoprotective proteins, in particular enzymes, which detoxify reactive oxygen species (ROS). Since ROS are produced in high amounts at the wound site as a defense against invading bacteria, the expression of these genes is most likely important for the protection of cells against these toxic molecules. In this review, we summarize the results on the expression of cytoprotective genes in wounded skin, and we discuss their possible roles in the wound-healing process.

Original languageEnglish
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume11
Issue number1
Pages (from-to)106-111
ISSN1087-0024
DOIs
Publication statusPublished - 2006
Externally publishedYes

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