Re-evaluation of azo dyes as food additives: Problems encountered

Iona Pratt, John Christian Larsen, Alicja Mortensen, Ivonne Rietjens

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Abstract

Aryl azo compounds are widely used as colorants (azo dyes) in a wide range of products including textiles, leather, paper, cosmetics, pharmaceuticals and food.As part of its systematic re-evaluation of food additives, the European Food Safety Authority (EFSA) has carried out new risk assessments of allazo dyes permitted in food. EFSA has also evaluated a number of azo dyes found illegally in food in recent years, including Sudan dyes, Para Red and Orange II. The re-evaluation of all food colours, including the azo dyes,was considered high priority (i) because colorants were among the first additives to be assessed by the Scientific Committee on Food, many years ago, (ii) because of concern regarding possible health effects of artificial colours arising since the original evaluations.Concerns includedbehavioural effects in children, allergic reactions, genotoxicity and possible carcinogenicity. Of the 11 previously authorisedazo dyes (Red 2 G, Tartrazine, Sunset Yellow FCF, Azorubine, Ponceau 4R, Allura Red AC, Amaranth, Brilliant Black BN, Brown FK, Brown HT and Litholrubine BK), the Acceptable Daily Intake (ADI) for Red 2G was withdrawn because of concerns regarding genotoxicity and carcinogenicity of its metabolite aniline. EFSA re-established ADIs for the other 10azodyes although those for Sunset Yellow FCF and Ponceau 4R were reduced, based on new toxicological data or re-interpretation of existing data. The regulatory consequences of EFSA's re-assessments include removal of the authorisation for Red 2G, new labelling provisions and reductions in the Maximum Permitted Levels for some azo dyes in food.

Copyright © 2013 Published by Elsevier Ireland Ltd.
Original languageEnglish
JournalToxicology Letters
Volume221
Issue numberSuppl.
Pages (from-to)53-53
ISSN0378-4274
DOIs
Publication statusPublished - 2013
Event49th Congress of the European Societies of Toxicology (EUROTOX) - Interlaken, Switzerland
Duration: 1 Sep 20134 Sep 2013
Conference number: 49

Conference

Conference49th Congress of the European Societies of Toxicology (EUROTOX)
Number49
CountrySwitzerland
CityInterlaken
Period01/09/201304/09/2013

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