Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium

Jørgen T. Hansen; Jens L. Sørensen; Henriette Giese; Teis E. Sondergaard; Rasmus J.N. Frandsen

doi:10.1016/j.ijfoodmicro.2012.01.018

Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium

Jørgen T. Hansen, Jens L. Sørensen, Henriette Giese, Teis E. Sondergaard, Rasmus J.N. Frandsen

Aarhus University

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides that give rise to health problems in animals and may have drug development potential. Using the genome sequences for Fusarium graminearum, F. oxysporum, F. solani and F. verticillioides we developed a framework for future polyketide synthases (PKSs) and nonribosomal peptides synthetases (NRPSs) nomenclature assignment and classification. Sequence similarities of the adenylation and ketosynthase domain sequences were used to group the identified NRPS and PKS genes. We present the current state of knowledge of PKS and NRPS genes in sequenced Fusarium species and their known products. With the rapid increase in the number of sequenced fungal genomes a systematic classification will greatly aid the scientific community in obtaining an overview of the number of different NRPS and PKS genes and their potential as producers of known bioactive compounds.

Original language	English
Journal	International Journal of Food Microbiology
Volume	155
Issue number	3
Pages (from-to)	128-136
ISSN	0168-1605
DOIs	https://doi.org/10.1016/j.ijfoodmicro.2012.01.018
Publication status	Published - 2012

Keywords

Fusarium
Nonribosomal peptide synthetase
Polyketide synthase
Secondary metabolism
Nomenclature

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10.1016/j.ijfoodmicro.2012.01.018

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title = "Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium",

abstract = "Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides that give rise to health problems in animals and may have drug development potential. Using the genome sequences for Fusarium graminearum, F. oxysporum, F. solani and F. verticillioides we developed a framework for future polyketide synthases (PKSs) and nonribosomal peptides synthetases (NRPSs) nomenclature assignment and classification. Sequence similarities of the adenylation and ketosynthase domain sequences were used to group the identified NRPS and PKS genes. We present the current state of knowledge of PKS and NRPS genes in sequenced Fusarium species and their known products. With the rapid increase in the number of sequenced fungal genomes a systematic classification will greatly aid the scientific community in obtaining an overview of the number of different NRPS and PKS genes and their potential as producers of known bioactive compounds.",

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T1 - Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium

AU - Hansen, Jørgen T.

AU - Sørensen, Jens L.

AU - Giese, Henriette

AU - Sondergaard, Teis E.

AU - Frandsen, Rasmus J.N.

PY - 2012

Y1 - 2012

N2 - Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides that give rise to health problems in animals and may have drug development potential. Using the genome sequences for Fusarium graminearum, F. oxysporum, F. solani and F. verticillioides we developed a framework for future polyketide synthases (PKSs) and nonribosomal peptides synthetases (NRPSs) nomenclature assignment and classification. Sequence similarities of the adenylation and ketosynthase domain sequences were used to group the identified NRPS and PKS genes. We present the current state of knowledge of PKS and NRPS genes in sequenced Fusarium species and their known products. With the rapid increase in the number of sequenced fungal genomes a systematic classification will greatly aid the scientific community in obtaining an overview of the number of different NRPS and PKS genes and their potential as producers of known bioactive compounds.

AB - Fusarium species produce a plethora of bioactive polyketides and nonribosomal peptides that give rise to health problems in animals and may have drug development potential. Using the genome sequences for Fusarium graminearum, F. oxysporum, F. solani and F. verticillioides we developed a framework for future polyketide synthases (PKSs) and nonribosomal peptides synthetases (NRPSs) nomenclature assignment and classification. Sequence similarities of the adenylation and ketosynthase domain sequences were used to group the identified NRPS and PKS genes. We present the current state of knowledge of PKS and NRPS genes in sequenced Fusarium species and their known products. With the rapid increase in the number of sequenced fungal genomes a systematic classification will greatly aid the scientific community in obtaining an overview of the number of different NRPS and PKS genes and their potential as producers of known bioactive compounds.

KW - Fusarium

KW - Nonribosomal peptide synthetase

KW - Polyketide synthase

KW - Secondary metabolism

KW - Nomenclature

U2 - 10.1016/j.ijfoodmicro.2012.01.018

DO - 10.1016/j.ijfoodmicro.2012.01.018

M3 - Journal article

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VL - 155

SP - 128

EP - 136

JO - International Journal of Food Microbiology

JF - International Journal of Food Microbiology

SN - 0168-1605

IS - 3

ER -

Quick guide to polyketide synthase and nonribosomal synthetase genes in Fusarium

Abstract

Keywords

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