Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide

Shuiping Liu; Tianxun Gu; Jiajia Fu; Xiaoqiang Li; Ioannis S. Chronakis; Mingqiao Ge

doi:10.1016/j.msec.2014.08.070

Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide

Shuiping Liu, Tianxun Gu, Jiajia Fu, Xiaoqiang Li, Ioannis S. Chronakis, Mingqiao Ge

National Food Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively. The nanospheres have spherical outline with dimension of ~ 127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability. The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.

Original language	English
Journal	Materials Science and Engineering C: Materials for Biological Applications
Volume	45
Pages (from-to)	37-44
Number of pages	8
DOIs	https://doi.org/10.1016/j.msec.2014.08.070
Publication status	Published - 2014

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@article{a2fb749cd916434394cc1fe88519ca65,

title = "Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide",

abstract = "In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively. The nanospheres have spherical outline with dimension of ~ 127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability. The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.",

author = "Shuiping Liu and Tianxun Gu and Jiajia Fu and Xiaoqiang Li and Chronakis, {Ioannis S.} and Mingqiao Ge",

year = "2014",

doi = "10.1016/j.msec.2014.08.070",

language = "English",

volume = "45",

pages = "37--44",

journal = "Materials Science and Engineering C: Materials for Biological Applications",

issn = "1873-0191",

publisher = "Elsevier",

}

Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide. / Liu, Shuiping; Gu, Tianxun; Fu, Jiajia; Li, Xiaoqiang; Chronakis, Ioannis S.; Ge, Mingqiao.

In: Materials Science and Engineering C: Materials for Biological Applications, Vol. 45, 2014, p. 37-44.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide

AU - Liu, Shuiping

AU - Gu, Tianxun

AU - Fu, Jiajia

AU - Li, Xiaoqiang

AU - Chronakis, Ioannis S.

AU - Ge, Mingqiao

PY - 2014

Y1 - 2014

N2 - In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively. The nanospheres have spherical outline with dimension of ~ 127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability. The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.

AB - In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively. The nanospheres have spherical outline with dimension of ~ 127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability. The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.

U2 - 10.1016/j.msec.2014.08.070

DO - 10.1016/j.msec.2014.08.070

M3 - Journal article

C2 - 25491799

VL - 45

SP - 37

EP - 44

JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

SN - 1873-0191

ER -