Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide

Shuiping Liu, Tianxun Gu, Jiajia Fu, Xiaoqiang Li, Ioannis S. Chronakis, Mingqiao Ge

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In this work, novel hybrid nanosphere vehicles were synthesized for nitric oxide (NO) donating and real-time detection. The hybrid nanosphere vehicles consist of cadmium selenide quantum dots (CdSe QDs) as NO fluorescent probes, and the modified hyperbranched polyether (mHP)-based diazeniumdiolates as NO donors, respectively. The nanospheres have spherical outline with dimension of ~ 127 nm. The data of systematic characterization demonstrated that the mHP-based hybrid nanosphere vehicles (QDs-mHP-NO) can release and real-time detect NO with the low limit of 25 nM, based on fluorescence quenching mechanism. The low cell-toxicity of QDs-mHP-NO nanospheres was verified by means of MTT assay on L929 cells viability. The QDs-mHP-NO nanospheres provide perspectives for designing a new class of biocompatible NO donating and imaging systems.
Original languageEnglish
JournalMaterials Science and Engineering C: Materials for Biological Applications
Volume45
Pages (from-to)37-44
Number of pages8
DOIs
Publication statusPublished - 2014

Fingerprint Dive into the research topics of 'Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide'. Together they form a unique fingerprint.

Cite this