Quantum dot-based nanosensors for diagnosis via enzyme activity measurement

Research output: Contribution to journalReview – Annual report year: 2013Researchpeer-review

Without internal affiliation

DOI

  • Author: Knudsen, Birgitta R.

    Aarhus University

  • Author: Jepsen, Morten Leth

    Aarhus University

  • Author: Ho, Yi Ping

    Aarhus University

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Enzymes are essential in the human body, and the disorder of enzymatic activities has been associated with many different diseases and stages of disease. Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have garnered great attention in molecular diagnostics. Owing to their superior optical properties, tunable and narrow emissions, stable brightness and long lifetime, QD-based enzyme activity measurement has demonstrated improved detection sensitivity, which is considered particularly valuable for early disease diagnosis. Recent studies have also shown that QD-based nanosensors are capable of probing multiple enzyme activities simultaneously. This review highlights the current development of QD-based nanosensors for enzyme detection. The enzyme-QD hybrid system, equipped with unique electronic, optical and catalytic properties, is envisioned as a potential solution in addressing challenges in diagnostics and therapeutics.

Original languageEnglish
JournalExpert Review of Molecular Diagnostics
Volume13
Issue number4
Pages (from-to)367-375
ISSN1473-7159
DOIs
Publication statusPublished - May 2013
Externally publishedYes
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Biosensors, Early disease diagnosis, Enzyme kinetics, Enzyme-nanoparticle conjugates, Nanomedicine

ID: 140589878