Quantum dot-based nanosensors for diagnosis via enzyme activity measurement

Birgitta R. Knudsen, Morten Leth Jepsen, Yi Ping Ho*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review


Enzymes are essential in the human body, and the disorder of enzymatic activities has been associated with many different diseases and stages of disease. Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have garnered great attention in molecular diagnostics. Owing to their superior optical properties, tunable and narrow emissions, stable brightness and long lifetime, QD-based enzyme activity measurement has demonstrated improved detection sensitivity, which is considered particularly valuable for early disease diagnosis. Recent studies have also shown that QD-based nanosensors are capable of probing multiple enzyme activities simultaneously. This review highlights the current development of QD-based nanosensors for enzyme detection. The enzyme-QD hybrid system, equipped with unique electronic, optical and catalytic properties, is envisioned as a potential solution in addressing challenges in diagnostics and therapeutics.

Original languageEnglish
JournalExpert Review of Molecular Diagnostics
Issue number4
Pages (from-to)367-375
Publication statusPublished - May 2013
Externally publishedYes


  • Biosensors
  • Early disease diagnosis
  • Enzyme kinetics
  • Enzyme-nanoparticle conjugates
  • Nanomedicine


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