Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Research output: Contribution to journalJournal article – Annual report year: 2014Researchpeer-review

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DOI

  • Author: Jepsen, Morten Leth

    Aarhus University

  • Author: Ottaviani, Alessio

    Aarhus University, Denmark

  • Author: Knudsen, Birgitta R.

    Aarhus University, Denmark

  • Author: Ho, Yi Ping

    Aarhus University, Denmark

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We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.
Original languageEnglish
JournalR S C Advances
Volume4
Pages (from-to)2491-2494
ISSN2046-2069
DOIs
Publication statusPublished - 2014
Externally publishedYes
CitationsWeb of Science® Times Cited: No match on DOI

ID: 140591079