Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Morten Leth Jepsen; Alessio Ottaviani; Birgitta R. Knudsen; Yi-Ping Ho

doi:10.1039/c3ra45557b

Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Morten Leth Jepsen
, Alessio Ottaviani
, Birgitta R. Knudsen
, Yi-Ping Ho

Aarhus University

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.

Original language	English
Journal	R S C Advances
Volume	4
Pages (from-to)	2491-2494
ISSN	2046-2069
DOIs	https://doi.org/10.1039/c3ra45557b
Publication status	Published - 2014
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c3ra45557b

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title = "Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I",

abstract = "We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.",

author = "Jepsen, \{Morten Leth\} and Alessio Ottaviani and Knudsen, \{Birgitta R.\} and Yi-Ping Ho",

year = "2014",

doi = "10.1039/c3ra45557b",

language = "English",

volume = "4",

pages = "2491--2494",

journal = "R S C Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

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T1 - Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

AU - Jepsen, Morten Leth

AU - Ottaviani, Alessio

AU - Knudsen, Birgitta R.

AU - Ho, Yi-Ping

PY - 2014

Y1 - 2014

N2 - We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.

AB - We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.

U2 - 10.1039/c3ra45557b

DO - 10.1039/c3ra45557b

M3 - Journal article

SN - 2046-2069

VL - 4

SP - 2491

EP - 2494

JO - R S C Advances

JF - R S C Advances

ER -

Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Abstract

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