Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I

Morten Leth Jepsen, Alessio Ottaviani, Birgitta R. Knudsen, Yi-Ping Ho

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.
Original languageEnglish
JournalR S C Advances
Volume4
Pages (from-to)2491-2494
ISSN2046-2069
DOIs
Publication statusPublished - 2014
Externally publishedYes

Cite this

Jepsen, Morten Leth ; Ottaviani, Alessio ; Knudsen, Birgitta R. ; Ho, Yi-Ping. / Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I. In: R S C Advances. 2014 ; Vol. 4. pp. 2491-2494.
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abstract = "We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.",
author = "Jepsen, {Morten Leth} and Alessio Ottaviani and Knudsen, {Birgitta R.} and Yi-Ping Ho",
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Quantum dot based DNA nanosensors for amplification-free detection of human topoisomerase I. / Jepsen, Morten Leth; Ottaviani, Alessio; Knudsen, Birgitta R.; Ho, Yi-Ping.

In: R S C Advances, Vol. 4, 2014, p. 2491-2494.

Research output: Contribution to journalJournal articleResearchpeer-review

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AB - We develop a quantum dot based DNA nanosensor specifically targeting the cleavage-religation activity of an essential DNA-modifying enzyme, human topoisomerase I. The assay has shown great promise in biological crude samples and thus is expected to contribute to clinical diagnostics and anti-cancer therapy.

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