Quantitative Label-Free Cell Proliferation Tracking with a Versatile Electrochemical Impedance Detection Platform

Claudia Caviglia, M Carminati, Arto Heiskanen, M Vergani, G Ferrari, M Sampietro, T L Andresen, Jenny Emnéus

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Since the use of impedance measurements for label-free monitoring of cells has become widespread but still the choice of sensing configuration is not unique though crucial for a quantitative interpretation of data, we demonstrate the application of a novel custom multipotentiostat platform to study optimal detection strategies. Electrochemical Impedance Spectroscopy (EIS) has been used to monitor and compare adhesion of different cell lines. HeLa cells and 3T3 fibroblasts have been cultured for 12 hours on interdigitated electrode arrays integrated into a tailor-made cell culture platform. Both vertical and coplanar interdigitated sensing configuration approaches have been used and compared on the same cell populations.
    Original languageEnglish
    Book seriesJournal of Physics: Conference Series (Online)
    Volume407
    Issue number1
    Pages (from-to)012029
    ISSN1742-6596
    DOIs
    Publication statusPublished - 2012

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