Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

Dennis Larsen; Andreas Erichsen; Giorgia Masciotta; Sebastian Meier; Sophie R. Beeren

doi:10.1039/d3cc05897b

Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

Dennis Larsen, Andreas Erichsen, Giorgia Masciotta, Sebastian Meier, Sophie R. Beeren^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Large-ring cyclodextrins (CDs) are a comparatively unexplored family of macrocycles. We use high-resolution ¹H-¹³C HSQC NMR experiments to resolve the anomeric signals of at least 13 different size CDs in a mixture. Using a single titration experiment, we can quantify the individual binding capabilites of these structurally-related hosts, avoiding the need for cumbersome isolation.

Original language	English
Journal	Chemical Communications
Volume	60
Pages (from-to)	2090–2093
ISSN	1359-7345
DOIs	https://doi.org/10.1039/d3cc05897b
Publication status	Published - 2024

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title = "Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures",

abstract = "Large-ring cyclodextrins (CDs) are a comparatively unexplored family of macrocycles. We use high-resolution 1H-13C HSQC NMR experiments to resolve the anomeric signals of at least 13 different size CDs in a mixture. Using a single titration experiment, we can quantify the individual binding capabilites of these structurally-related hosts, avoiding the need for cumbersome isolation.",

author = "Dennis Larsen and Andreas Erichsen and Giorgia Masciotta and Sebastian Meier and Beeren, {Sophie R.}",

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T1 - Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

AU - Larsen, Dennis

AU - Erichsen, Andreas

AU - Masciotta, Giorgia

AU - Meier, Sebastian

AU - Beeren, Sophie R.

PY - 2024

Y1 - 2024

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AB - Large-ring cyclodextrins (CDs) are a comparatively unexplored family of macrocycles. We use high-resolution 1H-13C HSQC NMR experiments to resolve the anomeric signals of at least 13 different size CDs in a mixture. Using a single titration experiment, we can quantify the individual binding capabilites of these structurally-related hosts, avoiding the need for cumbersome isolation.

U2 - 10.1039/d3cc05897b

DO - 10.1039/d3cc05897b

M3 - Journal article

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AN - SCOPUS:85183998167

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VL - 60

SP - 2090

EP - 2093

JO - Chemical Communications

JF - Chemical Communications

ER -

Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

Abstract

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