Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures

Dennis Larsen, Andreas Erichsen, Giorgia Masciotta, Sebastian Meier, Sophie R. Beeren*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Large-ring cyclodextrins (CDs) are a comparatively unexplored family of macrocycles. We use high-resolution 1H-13C HSQC NMR experiments to resolve the anomeric signals of at least 13 different size CDs in a mixture. Using a single titration experiment, we can quantify the individual binding capabilites of these structurally-related hosts, avoiding the need for cumbersome isolation.

Original languageEnglish
JournalChemical Communications
Volume60
Pages (from-to)2090–2093
ISSN1359-7345
DOIs
Publication statusPublished - 2024

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