Quantifying the importance of flow maldistribution in numbered-up microreactors

David Fernandes del Pozo; Timothy, Van Daele; Daan Van Hauwermeiren; Krist Gernaey; Ingmar Nopens

doi:10.1016/B978-0-444-63428-3.50209-5

Quantifying the importance of flow maldistribution in numbered-up microreactors

David Fernandes del Pozo, Timothy, Van Daele, Daan Van Hauwermeiren, Krist Gernaey, Ingmar Nopens

Department of Chemical and Biochemical Engineering

Ghent University

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

This article develops a methodology for quantifying the impact of flow maldistribution on theoverall performance of a numbered-up microreactor system. The methodology consists of thesimulation of multiple plug-flow microreactors in parallel where each microreactor is fed with acertain fraction of the total inlet flow. The modelling approach tests different flow maldistributionscenarios and quantifies their impact on the overall performance. This methodology can also befurther used to study a configuration with N-microreactors in parallel, and to evaluate the sensitivityof the reaction under study. The methodology is applied to two cases: 1) a test case, consistingof a first-order kinetic model, and 2) a case consisting of a conversion of benzylacetone and isopropylamineinto 1-methyl-2-phenylpropylamine and acetone catalyzed by an aminotransferase.The methodology was found to be very flexible and could be used to identify potential bottlenecksand opportunities in the numbering-up approach.

Original language	English
Title of host publication	Proceedings of the 26th European Symposium on Computer Aided Process Engineering
Editors	Zdravko Kravanja, Miloš Bogataj
Volume	38
Publisher	Elsevier
Publication date	2016
Pages	1225–1230
ISBN (Print)	978-0-444-63428-3
DOIs	https://doi.org/10.1016/B978-0-444-63428-3.50209-5
Publication status	Published - 2016
Event	26th European Symposium on Computer-Aided Process Engineering - Grand Hotel Bernardin Congress Centre, Portorož , Slovenia Duration: 12 Jun 2016 → 15 Jun 2016 http://escape26.um.si/

Conference

Conference	26th European Symposium on Computer-Aided Process Engineering
Location	Grand Hotel Bernardin Congress Centre
Country/Territory	Slovenia
City	Portorož
Period	12/06/2016 → 15/06/2016
Internet address	http://escape26.um.si/

Series	Computer Aided Chemical Engineering
Volume	38
ISSN	1570-7946

Keywords

Mathematical modelling
Kinetics
Methodology
Overall performance
Uncertainty analysis

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10.1016/B978-0-444-63428-3.50209-5

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Fernandes del Pozo, D., Daele, T. V., Van Hauwermeiren, D., Gernaey, K., & Nopens, I. (2016). Quantifying the importance of flow maldistribution in numbered-up microreactors. In Z. Kravanja, & M. Bogataj (Eds.), Proceedings of the 26th European Symposium on Computer Aided Process Engineering (Vol. 38, pp. 1225–1230). Elsevier. https://doi.org/10.1016/B978-0-444-63428-3.50209-5

Fernandes del Pozo, David ; Daele, Timothy, Van ; Van Hauwermeiren, Daan et al. / Quantifying the importance of flow maldistribution in numbered-up microreactors. Proceedings of the 26th European Symposium on Computer Aided Process Engineering. editor / Zdravko Kravanja ; Miloš Bogataj. Vol. 38 Elsevier, 2016. pp. 1225–1230 (Computer Aided Chemical Engineering, Vol. 38).

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Fernandes del Pozo, D, Daele, TV, Van Hauwermeiren, D, Gernaey, K & Nopens, I 2016, Quantifying the importance of flow maldistribution in numbered-up microreactors. in Z Kravanja & M Bogataj (eds), Proceedings of the 26th European Symposium on Computer Aided Process Engineering. vol. 38, Elsevier, Computer Aided Chemical Engineering, vol. 38, pp. 1225–1230, 26th European Symposium on Computer-Aided Process Engineering, Portorož , Slovenia, 12/06/2016. https://doi.org/10.1016/B978-0-444-63428-3.50209-5

Quantifying the importance of flow maldistribution in numbered-up microreactors. / Fernandes del Pozo, David; Daele, Timothy, Van; Van Hauwermeiren, Daan et al.
Proceedings of the 26th European Symposium on Computer Aided Process Engineering. ed. / Zdravko Kravanja; Miloš Bogataj. Vol. 38 Elsevier, 2016. p. 1225–1230 (Computer Aided Chemical Engineering, Vol. 38).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

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AB - This article develops a methodology for quantifying the impact of flow maldistribution on theoverall performance of a numbered-up microreactor system. The methodology consists of thesimulation of multiple plug-flow microreactors in parallel where each microreactor is fed with acertain fraction of the total inlet flow. The modelling approach tests different flow maldistributionscenarios and quantifies their impact on the overall performance. This methodology can also befurther used to study a configuration with N-microreactors in parallel, and to evaluate the sensitivityof the reaction under study. The methodology is applied to two cases: 1) a test case, consistingof a first-order kinetic model, and 2) a case consisting of a conversion of benzylacetone and isopropylamineinto 1-methyl-2-phenylpropylamine and acetone catalyzed by an aminotransferase.The methodology was found to be very flexible and could be used to identify potential bottlenecksand opportunities in the numbering-up approach.

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Fernandes del Pozo D, Daele TV, Van Hauwermeiren D, Gernaey K, Nopens I. Quantifying the importance of flow maldistribution in numbered-up microreactors. In Kravanja Z, Bogataj M, editors, Proceedings of the 26th European Symposium on Computer Aided Process Engineering. Vol. 38. Elsevier. 2016. p. 1225–1230. (Computer Aided Chemical Engineering, Vol. 38). doi: 10.1016/B978-0-444-63428-3.50209-5

Quantifying the importance of flow maldistribution in numbered-up microreactors

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