Quantification of Furan and 5 Alkylfurans with complete separation of 2-Ethylfuran and 2,5-Dimethylfuran isomers

Nancy Frank*, Mathieu Dubois, Khanh Hoang Nguyen, Arvid Fromberg, Thierry Delatour

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Alkylfurans have been found concurrently to furan in thermally processed food and might add to the overall exposure, thereby increase the health concern. The analytical methods developed for these compounds are based on gas chromatography separation coupled to mass spectrometry. Two of those alkylfurans, 2,5-dimethylfuran and 2-ethylfuran, are isomers, for which accurate quantification require either complete chromatographic separation or tandem mass spectrometry (MS/MS) selectivity. A new chromatographic method is reported using the Supelco Equity-1 column, demonstrating complete baseline separation of these two isomers, with a shorter runtime when using single mass spectrometry. Full validation was performed successfully for furan, 2- and 3-methylfuran, 2-ethylfuran, 2,5-dimethylfuran and 2-pentylfuran on different food matrices with recoveries in the range of 80 - 110 %, repeatability below 14 %, intermediate reproducibility below 22 % as well as expanded uncertainty under 50 %.
Original languageEnglish
Article number122765
JournalJournal of Chromatography B
ISSN1570-0232
DOIs
Publication statusAccepted/In press - 2021

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