Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

Moss Y. Zhao, Lena Václavů, Esben T. Petersen, Bart J. Biemond, Magdalena J. Sokolska, Yuriko Suzuki, David L. Thomas, Aart J. Nederveen, Michael A. Chappell*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose: To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo-QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post-labeling delay pseudo-continuous ASL (PCASL). Methods: A model-based method was developed to quantify CBF and arterial transit time (ATT) from Turbo-QUASAR, including a correction for magnetization transfer effects caused by the repeated labeling pulses. Simulations were performed to assess the accuracy of the model-based method. Data from an in vivo experiment conducted on a healthy cohort were retrospectively analyzed to compare the CBF and CVR (induced by acetazolamide) measurement from Turbo-QUASAR and PCASL on the basis of global and regional differences. The quality of the two ASL data sets was examined using the coefficient of variation (CoV). Results: The model-based method for Turbo-QUASAR was accurate for CBF estimation (relative error was 8% for signal-to-noise ratio = 5) in simulations if the bolus duration was known. In the in vivo experiment, the mean global CVR estimated by Turbo-QUASAR and PCASL was between 63% and 64% and not significantly different. Although global CBF values of the two ASL techniques were not significantly different, regional CBF differences were found in deep gray matter in both pre- and postacetazolamide conditions. The CoV of Turbo-QUASAR data was significantly higher than PCASL. Conclusion: Both ASL techniques were effective for quantifying CBF and CVR, despite the regional differences observed. Although CBF estimated from Turbo-QUASAR demonstrated a higher variability than PCASL, Turbo-QUASAR offers the advantage of being able to measure and control for variation in ATT.

Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume83
Issue number2
Pages (from-to)731-748
Number of pages18
ISSN0740-3194
DOIs
Publication statusPublished - 1 Feb 2020

Keywords

  • Arterial spin labeling
  • Cerebral blood flow
  • Cerebrovascular reserve
  • Pseudo-continuous arterial spin labeling
  • Pulsed arterial spin labeling
  • Turbo-QUASAR

Cite this

Zhao, Moss Y. ; Václavů, Lena ; Petersen, Esben T. ; Biemond, Bart J. ; Sokolska, Magdalena J. ; Suzuki, Yuriko ; Thomas, David L. ; Nederveen, Aart J. ; Chappell, Michael A. / Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI. In: Magnetic Resonance in Medicine. 2020 ; Vol. 83, No. 2. pp. 731-748.
@article{dfe48ac9b9414cd380ef1e882d1d2bab,
title = "Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI",
abstract = "Purpose: To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo-QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post-labeling delay pseudo-continuous ASL (PCASL). Methods: A model-based method was developed to quantify CBF and arterial transit time (ATT) from Turbo-QUASAR, including a correction for magnetization transfer effects caused by the repeated labeling pulses. Simulations were performed to assess the accuracy of the model-based method. Data from an in vivo experiment conducted on a healthy cohort were retrospectively analyzed to compare the CBF and CVR (induced by acetazolamide) measurement from Turbo-QUASAR and PCASL on the basis of global and regional differences. The quality of the two ASL data sets was examined using the coefficient of variation (CoV). Results: The model-based method for Turbo-QUASAR was accurate for CBF estimation (relative error was 8{\%} for signal-to-noise ratio = 5) in simulations if the bolus duration was known. In the in vivo experiment, the mean global CVR estimated by Turbo-QUASAR and PCASL was between 63{\%} and 64{\%} and not significantly different. Although global CBF values of the two ASL techniques were not significantly different, regional CBF differences were found in deep gray matter in both pre- and postacetazolamide conditions. The CoV of Turbo-QUASAR data was significantly higher than PCASL. Conclusion: Both ASL techniques were effective for quantifying CBF and CVR, despite the regional differences observed. Although CBF estimated from Turbo-QUASAR demonstrated a higher variability than PCASL, Turbo-QUASAR offers the advantage of being able to measure and control for variation in ATT.",
keywords = "Arterial spin labeling, Cerebral blood flow, Cerebrovascular reserve, Pseudo-continuous arterial spin labeling, Pulsed arterial spin labeling, Turbo-QUASAR",
author = "Zhao, {Moss Y.} and Lena V{\'a}clavů and Petersen, {Esben T.} and Biemond, {Bart J.} and Sokolska, {Magdalena J.} and Yuriko Suzuki and Thomas, {David L.} and Nederveen, {Aart J.} and Chappell, {Michael A.}",
year = "2020",
month = "2",
day = "1",
doi = "10.1002/mrm.27956",
language = "English",
volume = "83",
pages = "731--748",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

Zhao, MY, Václavů, L, Petersen, ET, Biemond, BJ, Sokolska, MJ, Suzuki, Y, Thomas, DL, Nederveen, AJ & Chappell, MA 2020, 'Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI', Magnetic Resonance in Medicine, vol. 83, no. 2, pp. 731-748. https://doi.org/10.1002/mrm.27956

Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI. / Zhao, Moss Y.; Václavů, Lena; Petersen, Esben T.; Biemond, Bart J.; Sokolska, Magdalena J.; Suzuki, Yuriko; Thomas, David L.; Nederveen, Aart J.; Chappell, Michael A.

In: Magnetic Resonance in Medicine, Vol. 83, No. 2, 01.02.2020, p. 731-748.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

AU - Zhao, Moss Y.

AU - Václavů, Lena

AU - Petersen, Esben T.

AU - Biemond, Bart J.

AU - Sokolska, Magdalena J.

AU - Suzuki, Yuriko

AU - Thomas, David L.

AU - Nederveen, Aart J.

AU - Chappell, Michael A.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Purpose: To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo-QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post-labeling delay pseudo-continuous ASL (PCASL). Methods: A model-based method was developed to quantify CBF and arterial transit time (ATT) from Turbo-QUASAR, including a correction for magnetization transfer effects caused by the repeated labeling pulses. Simulations were performed to assess the accuracy of the model-based method. Data from an in vivo experiment conducted on a healthy cohort were retrospectively analyzed to compare the CBF and CVR (induced by acetazolamide) measurement from Turbo-QUASAR and PCASL on the basis of global and regional differences. The quality of the two ASL data sets was examined using the coefficient of variation (CoV). Results: The model-based method for Turbo-QUASAR was accurate for CBF estimation (relative error was 8% for signal-to-noise ratio = 5) in simulations if the bolus duration was known. In the in vivo experiment, the mean global CVR estimated by Turbo-QUASAR and PCASL was between 63% and 64% and not significantly different. Although global CBF values of the two ASL techniques were not significantly different, regional CBF differences were found in deep gray matter in both pre- and postacetazolamide conditions. The CoV of Turbo-QUASAR data was significantly higher than PCASL. Conclusion: Both ASL techniques were effective for quantifying CBF and CVR, despite the regional differences observed. Although CBF estimated from Turbo-QUASAR demonstrated a higher variability than PCASL, Turbo-QUASAR offers the advantage of being able to measure and control for variation in ATT.

AB - Purpose: To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo-QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post-labeling delay pseudo-continuous ASL (PCASL). Methods: A model-based method was developed to quantify CBF and arterial transit time (ATT) from Turbo-QUASAR, including a correction for magnetization transfer effects caused by the repeated labeling pulses. Simulations were performed to assess the accuracy of the model-based method. Data from an in vivo experiment conducted on a healthy cohort were retrospectively analyzed to compare the CBF and CVR (induced by acetazolamide) measurement from Turbo-QUASAR and PCASL on the basis of global and regional differences. The quality of the two ASL data sets was examined using the coefficient of variation (CoV). Results: The model-based method for Turbo-QUASAR was accurate for CBF estimation (relative error was 8% for signal-to-noise ratio = 5) in simulations if the bolus duration was known. In the in vivo experiment, the mean global CVR estimated by Turbo-QUASAR and PCASL was between 63% and 64% and not significantly different. Although global CBF values of the two ASL techniques were not significantly different, regional CBF differences were found in deep gray matter in both pre- and postacetazolamide conditions. The CoV of Turbo-QUASAR data was significantly higher than PCASL. Conclusion: Both ASL techniques were effective for quantifying CBF and CVR, despite the regional differences observed. Although CBF estimated from Turbo-QUASAR demonstrated a higher variability than PCASL, Turbo-QUASAR offers the advantage of being able to measure and control for variation in ATT.

KW - Arterial spin labeling

KW - Cerebral blood flow

KW - Cerebrovascular reserve

KW - Pseudo-continuous arterial spin labeling

KW - Pulsed arterial spin labeling

KW - Turbo-QUASAR

U2 - 10.1002/mrm.27956

DO - 10.1002/mrm.27956

M3 - Journal article

VL - 83

SP - 731

EP - 748

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 2

ER -