Quantification and validation of soft tissue deformation

Thomas Hammershaimb Mosbech, Bjarne Kjær Ersbøll, Lars Bager Christensen

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch


    We present a model for soft tissue deformation derived empirically from 10 pig carcases. The carcasses are subjected to deformation from a known single source of pressure located at the skin surface, and the deformation is quantified by means of steel markers injected into the tissue. The steel markers are easy to distinguish from the surrounding soft tissue in 3D computed tomography images. By tracking corresponding markers using methods from point-based registration, we are able to accurately quantify the magnitude and propagation of the induced deformation. The deformation is parameterised by radial basis functions with compact support. The parameterisation yields an absolute error with mean 0.20 mm, median 0.13 mm and standard deviation 0.21 mm (not cross validated). We use the parameterisation to form a statistical deformation model applying principal component analysis on the estimated deformation parameters. The model is successfully validated using leave-one-out cross validation by subject, achieving a sufficient level of precision using only the first two principal modes; mean 1.22 mm, median 1.11 mm and standard deviation 0.67 mm.
    Original languageEnglish
    Title of host publicationMedical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging
    EditorsP. Hu Xiaoping, Anne V. Clough
    Number of pages8
    PublisherSPIE - International Society for Optical Engineering
    Publication date2009
    Publication statusPublished - 2009
    EventQuantification and validation of soft tissue deformation - Lake Buena Vista, FL, USA
    Duration: 1 Jan 2009 → …


    ConferenceQuantification and validation of soft tissue deformation
    CityLake Buena Vista, FL, USA
    Period01/01/2009 → …


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