Abstract
The focus of the EU FP7 project ChemScreen, which was completed by the end of 2013, was to
generate alternative testing methods for reproductive toxicity under REACH. If found adequate,
QSARs can be applied in REACH as a replacement for animal tests. As no testing for
reproductive effects should be performed in REACH on known genotoxic carcinogens or germ
cell mutagens with appropriate risk management measures implemented, a QSAR pre-screen for
genotoxic carcinogenicity, germ cell mutagenicity and (limited) developmental toxicity was
included in the project. Predictions for estrogenic and anti-androgenic activity (in vitro) were
also included in the pre-screen. The prediction set comprised 70,983 of the 143,835 chemicals
REACH pre-registered chemicals, for which structural information was found and was suitable
for the applied QSAR models. The prediction set was run through 16 models and decision
algorithms were applied to combine the predictions from the individual models to reach overall
predictions for genotoxic carcinogenicity, germ cell mutagenicity and developmental toxicity.
Furthermore, the full list of REACH pre-registered substances (143,835) was searched for
substances containing certain known toxic heavy metals (Cd, As, Hg and Pb) and these were
flagged as they may be assumed to possess the properties of the heavy metal part unless
otherwise known. The QSAR pre-screen results were fed into subsequent ChemScreen activities
to develop an in vitro/in silico screening system to predict human- and ecotoxicological effects.
Original language | English |
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Title of host publication | Abstract Book - DTU Sustain Conference 2014 |
Number of pages | 1 |
Place of Publication | Kgs. Lyngby |
Publisher | Technical University of Denmark |
Publication date | 2014 |
Publication status | Published - 2014 |
Event | DTU Sustain Conference 2014 - Technical University of Denmark, Lyngby, Denmark Duration: 17 Dec 2014 → 17 Dec 2014 http://www.sustain.dtu.dk/ |
Conference
Conference | DTU Sustain Conference 2014 |
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Location | Technical University of Denmark |
Country/Territory | Denmark |
City | Lyngby |
Period | 17/12/2014 → 17/12/2014 |
Internet address |