Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea

Chris Juul Hedegaard, Charlotte Lauridsen, Peter M. H. Heegaard

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    Abstract

    Enteric infectious disease in weaner piglets, including postweaning diarrhoea (PWD), are usually treated and/or prevented with antibiotics and/or zinc oxide in the piglet feed. However extensive use of antibiotics and zinc oxide in intensive animal production is unwanted as it may promote microbial antibiotic resistance and pose environmental problems. Recently, in an experimental model of PWD, we observed that oral administration of purified porcine immunoglobulin G (ppIgG) from pooled natural pig plasma could reduce enteric infection. In the present study we were able to reproduce these results as it was observed that oral ppIgG accelerated clearance of faecal haemolytic bacteria in pigs challenged with E. coli in comparison with pigs not receiving ppIgG. This effect was observed upon feeding ppIgG for seven days postweaning suggesting that ppIgG does not have to be used prophylactically for several days preweaning. Furthermore, the effect of oral administration of ppIgG for seven days postweaning was equal to or better than that of dietary zinc oxide in reducing diarrhoea symptoms and in clearing faecal haemolytic bacteria for 14 days postweaning. These observations warrant future trials of dietary ppIgG in intensive swine production units to establish its performance as an alternative to dietary antibiotics and zinc oxide for preventing PWD.
    Original languageEnglish
    JournalVeterinary Immunology and Immunopathology
    Volume186
    Pages (from-to)9-14
    ISSN0165-2427
    DOIs
    Publication statusPublished - 2017

    Cite this

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    title = "Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea",
    abstract = "Enteric infectious disease in weaner piglets, including postweaning diarrhoea (PWD), are usually treated and/or prevented with antibiotics and/or zinc oxide in the piglet feed. However extensive use of antibiotics and zinc oxide in intensive animal production is unwanted as it may promote microbial antibiotic resistance and pose environmental problems. Recently, in an experimental model of PWD, we observed that oral administration of purified porcine immunoglobulin G (ppIgG) from pooled natural pig plasma could reduce enteric infection. In the present study we were able to reproduce these results as it was observed that oral ppIgG accelerated clearance of faecal haemolytic bacteria in pigs challenged with E. coli in comparison with pigs not receiving ppIgG. This effect was observed upon feeding ppIgG for seven days postweaning suggesting that ppIgG does not have to be used prophylactically for several days preweaning. Furthermore, the effect of oral administration of ppIgG for seven days postweaning was equal to or better than that of dietary zinc oxide in reducing diarrhoea symptoms and in clearing faecal haemolytic bacteria for 14 days postweaning. These observations warrant future trials of dietary ppIgG in intensive swine production units to establish its performance as an alternative to dietary antibiotics and zinc oxide for preventing PWD.",
    author = "Hedegaard, {Chris Juul} and Charlotte Lauridsen and Heegaard, {Peter M. H.}",
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    language = "English",
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    Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea. / Hedegaard, Chris Juul; Lauridsen, Charlotte; Heegaard, Peter M. H.

    In: Veterinary Immunology and Immunopathology, Vol. 186, 2017, p. 9-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Purified natural pig immunoglobulins can substitute dietary zinc in reducing piglet post weaning diarrhoea

    AU - Hedegaard, Chris Juul

    AU - Lauridsen, Charlotte

    AU - Heegaard, Peter M. H.

    PY - 2017

    Y1 - 2017

    N2 - Enteric infectious disease in weaner piglets, including postweaning diarrhoea (PWD), are usually treated and/or prevented with antibiotics and/or zinc oxide in the piglet feed. However extensive use of antibiotics and zinc oxide in intensive animal production is unwanted as it may promote microbial antibiotic resistance and pose environmental problems. Recently, in an experimental model of PWD, we observed that oral administration of purified porcine immunoglobulin G (ppIgG) from pooled natural pig plasma could reduce enteric infection. In the present study we were able to reproduce these results as it was observed that oral ppIgG accelerated clearance of faecal haemolytic bacteria in pigs challenged with E. coli in comparison with pigs not receiving ppIgG. This effect was observed upon feeding ppIgG for seven days postweaning suggesting that ppIgG does not have to be used prophylactically for several days preweaning. Furthermore, the effect of oral administration of ppIgG for seven days postweaning was equal to or better than that of dietary zinc oxide in reducing diarrhoea symptoms and in clearing faecal haemolytic bacteria for 14 days postweaning. These observations warrant future trials of dietary ppIgG in intensive swine production units to establish its performance as an alternative to dietary antibiotics and zinc oxide for preventing PWD.

    AB - Enteric infectious disease in weaner piglets, including postweaning diarrhoea (PWD), are usually treated and/or prevented with antibiotics and/or zinc oxide in the piglet feed. However extensive use of antibiotics and zinc oxide in intensive animal production is unwanted as it may promote microbial antibiotic resistance and pose environmental problems. Recently, in an experimental model of PWD, we observed that oral administration of purified porcine immunoglobulin G (ppIgG) from pooled natural pig plasma could reduce enteric infection. In the present study we were able to reproduce these results as it was observed that oral ppIgG accelerated clearance of faecal haemolytic bacteria in pigs challenged with E. coli in comparison with pigs not receiving ppIgG. This effect was observed upon feeding ppIgG for seven days postweaning suggesting that ppIgG does not have to be used prophylactically for several days preweaning. Furthermore, the effect of oral administration of ppIgG for seven days postweaning was equal to or better than that of dietary zinc oxide in reducing diarrhoea symptoms and in clearing faecal haemolytic bacteria for 14 days postweaning. These observations warrant future trials of dietary ppIgG in intensive swine production units to establish its performance as an alternative to dietary antibiotics and zinc oxide for preventing PWD.

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    DO - 10.1016/j.vetimm.2017.02.001

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