Psychrophilin A and cycloaspeptide D, novel cyclic peptides from the psychrotolerant fungus Penicillium ribeum

Petur Dalsgaard, Thomas Ostenfeld Larsen, K. Frydenvang, C. Christophersen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Two fungal metabolites, psychrophilin A (1) and cycloaspeptide D (2), together with the known cycloaspeptide A (3) were isolated from the psychrotolerant fungus Penicillium ribeum. using high-speed countercurrent chromatography (HSCCC) and preparative HPLC. The structures were determined from 1D and 2D NMR techniques, HREIMS, tandem mass spectrometry (ESMS/MS), and X-ray crystallography. The amino acid residues of psychrophilin A (1) and cycloaspeptide D (2) were all found to possess the L configuration by Marfey's method. Psychrophilin A (1) is the first natural cyclic peptide containing a nitro group instead of an amino group.
    Original languageEnglish
    JournalJournal of Natural Products
    Volume67
    Pages (from-to)878-881
    ISSN0163-3864
    Publication statusPublished - 2004

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