Pseudogene repair driven by selection pressure applied in experimental evolution

Amitesh Anand; Connor A. Olson; Laurence Yang; Anand V. Sastry; Edward Catoiu; Kumari Sonal Choudhary; Patrick V. Phaneuf; Troy E. Sandberg; Sibei Xu; Ying Hefner; Richard Szubin; Adam Feist; Bernhard Palsson

doi:10.1038/s41564-018-0340-2

Pseudogene repair driven by selection pressure applied in experimental evolution

Amitesh Anand, Connor A. Olson, Laurence Yang, Anand V. Sastry, Edward Catoiu, Kumari Sonal Choudhary, Patrick V. Phaneuf, Troy E. Sandberg, Sibei Xu, Ying Hefner, Richard Szubin, Adam Feist, Bernhard Palsson^*

^*Corresponding author for this work

Novo Nordisk Foundation Center for Biosustainability

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially ‘wasteful’. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.

Original language	English
Journal	Nature Microbiology
Volume	4
Issue number	3
Pages (from-to)	386-389
ISSN	2058-5276
DOIs	https://doi.org/10.1038/s41564-018-0340-2
Publication status	Published - 2019

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title = "Pseudogene repair driven by selection pressure applied in experimental evolution",

abstract = "Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially {\textquoteleft}wasteful{\textquoteright}. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.",

author = "Amitesh Anand and Olson, {Connor A.} and Laurence Yang and Sastry, {Anand V.} and Edward Catoiu and Choudhary, {Kumari Sonal} and Phaneuf, {Patrick V.} and Sandberg, {Troy E.} and Sibei Xu and Ying Hefner and Richard Szubin and Adam Feist and Bernhard Palsson",

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doi = "10.1038/s41564-018-0340-2",

language = "English",

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AU - Anand, Amitesh

AU - Olson, Connor A.

AU - Yang, Laurence

AU - Sastry, Anand V.

AU - Catoiu, Edward

AU - Choudhary, Kumari Sonal

AU - Phaneuf, Patrick V.

AU - Sandberg, Troy E.

AU - Xu, Sibei

AU - Hefner, Ying

AU - Szubin, Richard

AU - Feist, Adam

AU - Palsson, Bernhard

PY - 2019

Y1 - 2019

N2 - Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially ‘wasteful’. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.

AB - Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially ‘wasteful’. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.

U2 - 10.1038/s41564-018-0340-2

DO - 10.1038/s41564-018-0340-2

M3 - Journal article

C2 - 30692668

SN - 2058-5276

VL - 4

SP - 386

EP - 389

JO - Nature Microbiology

JF - Nature Microbiology

IS - 3

ER -

Pseudogene repair driven by selection pressure applied in experimental evolution

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