Pseudogene repair driven by selection pressure applied in experimental evolution

Amitesh Anand, Connor A. Olson, Laurence Yang, Anand V. Sastry, Edward Catoiu, Kumari Sonal Choudhary, Patrick V. Phaneuf, Troy E. Sandberg, Sibei Xu, Ying Hefner, Richard Szubin, Adam Feist, Bernhard Palsson*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially ‘wasteful’. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.
Original languageEnglish
JournalNature Microbiology
Issue number3
Pages (from-to)386-389
Publication statusPublished - 2019


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