PSE opportunities in biocatalytic process design and development

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Abstract

Biocatalysis (the use of one or more isolated enzymes in soluble or immobilized form, as well as enzymes contained within resting whole-cells) is a rapidly growing area of process technology. The introduction of biocatalysis presents new opportunities to develop ‘green’ synthetic routes to pharmaceuticals and other chemical products, since enzymes usually work in an aqueous solution and under mild conditions. Nevertheless the implementation of a biocatalytic reaction and the integration of a biocatalytic reaction into an otherwise chemical catalytic sequence is a complex task where PSE tools have a particularly important role to play. In this paper we will present a variety of PSE tools including computational fluid dynamics (CFD), operating windows, kinetic modelling, economic analysis and environmental assessment to support the development of economically viable biocatalytic processes.
Original languageEnglish
Title of host publicationProceedings of the 11th International Symposium on Process Systems Engineering
EditorsI.A. Karimi, Rajagopalan Srinivasa
PublisherElsevier
Publication date2012
Pages875-879
Publication statusPublished - 2012
Event11th International Symposium on Process Systems Engineering - , Singapore
Duration: 15 Jul 201219 Jul 2012

Conference

Conference11th International Symposium on Process Systems Engineering
CountrySingapore
Period15/07/201219/07/2012
SeriesComputer Aided Chemical Engineering
Volume31
ISSN1570-7946

Bibliographical note

Oral presentation.

Keywords

  • Process template
  • Substrate adoption
  • Methodology
  • Pharmaceutical

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