Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial
fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We
investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR).
Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican
and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher
in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p <
0.001) and moderately correlated to extracellular volume (r2 = 0.38, p<0.001 and r2 = 0.26, p = 0.015). Turnover of biglycan and
versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link
between angina with no obstructive CAD and fibrotic remodeling.
- Angina pectoris
- T1 mapping
- Cardiac magnetic resonance
- Coronary microvascular disease
- Diffuse myocardial fibrosis
- Extracellular matrix