Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study

Naja Dam Mygind; Signe Holm Nielsen; Marie Mide Michelsen; Adam Pena; Daria Frestad Bechsgaard; Elena Suhrs; Kira Bang Bove; Federica Genovese; Henning Bay Nielsen; Morten Karsdal; Niels Vejlstrup; Eva Prescott; Jens Kastrup

doi:10.1007/s12265-021-10106-y

Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study

Naja Dam Mygind^*, Signe Holm Nielsen, Marie Mide Michelsen, Adam Pena, Daria Frestad Bechsgaard, Elena Suhrs, Kira Bang Bove, Federica Genovese, Henning Bay Nielsen, Morten Karsdal, Niels Vejlstrup, Eva Prescott, Jens Kastrup

^*Corresponding author for this work

Department of Biotechnology and Biomedicine

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r² = 0.38, p<0.001 and r² = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.

Original language	English
Journal	Journal of Cardiovascular Translational Research
Volume	14
Pages (from-to)	921-929
Number of pages	9
ISSN	1937-5387
DOIs	https://doi.org/10.1007/s12265-021-10106-y
Publication status	Published - 2021

Keywords

Proteoglycan
Angina pectoris
T1 mapping
Cardiac magnetic resonance
Coronary microvascular disease
Diffuse myocardial fibrosis
Extracellular matrix

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10.1007/s12265-021-10106-y

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Mygind, N. D., Nielsen, S. H., Michelsen, M. M., Pena, A., Bechsgaard, D. F., Suhrs, E., Bove, K. B., Genovese, F., Nielsen, H. B., Karsdal, M., Vejlstrup, N., Prescott, E., & Kastrup, J. (2021). Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study. Journal of Cardiovascular Translational Research, 14, 921-929. https://doi.org/10.1007/s12265-021-10106-y

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title = "Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study",

abstract = "Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r2 = 0.38, p<0.001 and r2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.",

keywords = "Proteoglycan, Angina pectoris, T1 mapping, Cardiac magnetic resonance, Coronary microvascular disease, Diffuse myocardial fibrosis, Extracellular matrix",

author = "Mygind, {Naja Dam} and Nielsen, {Signe Holm} and Michelsen, {Marie Mide} and Adam Pena and Bechsgaard, {Daria Frestad} and Elena Suhrs and Bove, {Kira Bang} and Federica Genovese and Nielsen, {Henning Bay} and Morten Karsdal and Niels Vejlstrup and Eva Prescott and Jens Kastrup",

year = "2021",

doi = "10.1007/s12265-021-10106-y",

language = "English",

volume = "14",

pages = "921--929",

journal = "Journal of Cardiovascular Translational Research",

issn = "1937-5387",

publisher = "Springer New York",

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Mygind, ND, Nielsen, SH, Michelsen, MM, Pena, A, Bechsgaard, DF, Suhrs, E, Bove, KB, Genovese, F, Nielsen, HB, Karsdal, M, Vejlstrup, N, Prescott, E & Kastrup, J 2021, 'Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study', Journal of Cardiovascular Translational Research, vol. 14, pp. 921-929. https://doi.org/10.1007/s12265-021-10106-y

TY - JOUR

T1 - Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study

AU - Mygind, Naja Dam

AU - Nielsen, Signe Holm

AU - Michelsen, Marie Mide

AU - Pena, Adam

AU - Bechsgaard, Daria Frestad

AU - Suhrs, Elena

AU - Bove, Kira Bang

AU - Genovese, Federica

AU - Nielsen, Henning Bay

AU - Karsdal, Morten

AU - Vejlstrup, Niels

AU - Prescott, Eva

AU - Kastrup, Jens

PY - 2021

Y1 - 2021

N2 - Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r2 = 0.38, p<0.001 and r2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.

AB - Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r2 = 0.38, p<0.001 and r2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.

KW - Proteoglycan

KW - Angina pectoris

KW - T1 mapping

KW - Cardiac magnetic resonance

KW - Coronary microvascular disease

KW - Diffuse myocardial fibrosis

KW - Extracellular matrix

U2 - 10.1007/s12265-021-10106-y

DO - 10.1007/s12265-021-10106-y

M3 - Journal article

C2 - 33649986

SN - 1937-5387

VL - 14

SP - 921

EP - 929

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

ER -

Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study

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Keywords

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