Proteinaceous alpha-araylase inhibitors.

Birte Svensson, Kenji Fukuda, P.K. Nielsen, Birgit Christine Bønsager

    Research output: Contribution to journalJournal articleResearchpeer-review


    Proteins that inhibit alpha-amylases have been isolated from plants and microorganisms. These inhibitors can have natural roles in the control of endogenous a-amylase activity or in defence against pathogens and pests; certain inhibitors are reported to be antinutritional factors. The alpha-amylase inhibitors belong to seven different protein structural families, most of which also contain evolutionary related proteins without inhibitory activity. Two families include bifunctional inhibitors acting both on alpha-amylases and proteases. High-resolution structures are available of target alpha-amylases in complex with inhibitors from five families. These structures indicate major diversity but also some similarity in the structural basis of alpha-amylase inhibition. Mutational analysis of the mechanism of inhibition was performed in a few cases and various protein engineering and biotechnological approaches have been outlined for exploitation of the inhibitory function.
    Original languageEnglish
    JournalBBA General Subjects
    Pages (from-to)145-156
    Publication statusPublished - 2004


    Dive into the research topics of 'Proteinaceous alpha-araylase inhibitors.'. Together they form a unique fingerprint.

    Cite this