Protein repellent hydrophilic grafts prepared by surface-initiated atom transfer radical polymerization from polypropylene

Charlotte Juel Fristrup; Katja Jankova Atanasova; Rüya Eskimergen; Jens T. Bukrinsky; Søren Hvilsted

doi:10.1039/c1py00347j

Protein repellent hydrophilic grafts prepared by surface-initiated atom transfer radical polymerization from polypropylene

Charlotte Juel Fristrup, Katja Jankova Atanasova, Rüya Eskimergen, Jens T. Bukrinsky, Søren Hvilsted

Novo Nordisk Foundation

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Abstract

Grafting of poly(ethylene glycol)methacrylate (PEGMA) and N,N-dimethylacrylamide (DMAAm) from UV-initiator modified polypropylene (PP) was performed by Surface-Initiated Atom Transfer Radical Polymerization (SI-ATRP). The modification and hydrophilization of the PP substrates were confirmed with Attenuated Total Reflectance (ATR) Fourier Transform Infrared (FTIR) spectroscopy and Water Contact Angle (WCA) measurements. Confocal fluorescence microscopy of modified and unmodified substrates immersed in labelled insulin aspart showed superior repulsion of this protein for the poly(PEGMA) grafts, due to the achieved architecture.

Original language	English
Journal	Polymer Chemistry
Volume	3
Issue number	1
Pages (from-to)	198-203
ISSN	1759-9954
DOIs	https://doi.org/10.1039/c1py00347j
Publication status	Published - 2012

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title = "Protein repellent hydrophilic grafts prepared by surface-initiated atom transfer radical polymerization from polypropylene",

abstract = "Grafting of poly(ethylene glycol)methacrylate (PEGMA) and N,N-dimethylacrylamide (DMAAm) from UV-initiator modified polypropylene (PP) was performed by Surface-Initiated Atom Transfer Radical Polymerization (SI-ATRP). The modification and hydrophilization of the PP substrates were confirmed with Attenuated Total Reflectance (ATR) Fourier Transform Infrared (FTIR) spectroscopy and Water Contact Angle (WCA) measurements. Confocal fluorescence microscopy of modified and unmodified substrates immersed in labelled insulin aspart showed superior repulsion of this protein for the poly(PEGMA) grafts, due to the achieved architecture.",

author = "Fristrup, {Charlotte Juel} and {Jankova Atanasova}, Katja and R{\"u}ya Eskimergen and Bukrinsky, {Jens T.} and S{\o}ren Hvilsted",

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year = "2012",

doi = "10.1039/c1py00347j",

language = "English",

volume = "3",

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T1 - Protein repellent hydrophilic grafts prepared by surface-initiated atom transfer radical polymerization from polypropylene

AU - Fristrup, Charlotte Juel

AU - Jankova Atanasova, Katja

AU - Eskimergen, Rüya

AU - Bukrinsky, Jens T.

AU - Hvilsted, Søren

PY - 2012

Y1 - 2012

N2 - Grafting of poly(ethylene glycol)methacrylate (PEGMA) and N,N-dimethylacrylamide (DMAAm) from UV-initiator modified polypropylene (PP) was performed by Surface-Initiated Atom Transfer Radical Polymerization (SI-ATRP). The modification and hydrophilization of the PP substrates were confirmed with Attenuated Total Reflectance (ATR) Fourier Transform Infrared (FTIR) spectroscopy and Water Contact Angle (WCA) measurements. Confocal fluorescence microscopy of modified and unmodified substrates immersed in labelled insulin aspart showed superior repulsion of this protein for the poly(PEGMA) grafts, due to the achieved architecture.

AB - Grafting of poly(ethylene glycol)methacrylate (PEGMA) and N,N-dimethylacrylamide (DMAAm) from UV-initiator modified polypropylene (PP) was performed by Surface-Initiated Atom Transfer Radical Polymerization (SI-ATRP). The modification and hydrophilization of the PP substrates were confirmed with Attenuated Total Reflectance (ATR) Fourier Transform Infrared (FTIR) spectroscopy and Water Contact Angle (WCA) measurements. Confocal fluorescence microscopy of modified and unmodified substrates immersed in labelled insulin aspart showed superior repulsion of this protein for the poly(PEGMA) grafts, due to the achieved architecture.

U2 - 10.1039/c1py00347j

DO - 10.1039/c1py00347j

M3 - Journal article

SN - 1759-9954

VL - 3

SP - 198

EP - 203

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 1

ER -

Protein repellent hydrophilic grafts prepared by surface-initiated atom transfer radical polymerization from polypropylene

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