Protein phosphorylation in bacterial signal transduction

Ahasanul Kobir, Lei Shi, Ana Boskovic, Christophe Grangeasse, Damjan Franjevic, Ivan Mijakovic, Stefan Hohmann Marcus Krantz

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

BackgroundProtein phosphorylation has emerged as one of the major post translational modifications in bacteria, involved in regulating a myriad of physiological processes. In a complex and dynamic system such as the bacterial cell, connectivity of its components accounts for a number of emergent properties. This article is part of a Special Issue entitled: Systems Biology of Microorganisms. Scope of reviewThis review focuses on the implications of bacterial protein phosphorylation in cell signaling and regulation and highlights the connections and cross talk between various signaling pathways: bacterial two-component systems and serine/threonine kinases, but also the interference between phosphorylation and other post-translational modifications (methylation and acetylation). Major conclusionsRecent technical developments in high accuracy mass spectrometry have profoundly transformed proteomics, and today exhaustive site-specific phosphoproteomes are available for a number of bacterial species. Nevertheless, prediction of phosphorylation sites remains the main guide for many researchers, so we discuss the characteristics, limits and advantages of available phosphorylation predictors. General significanceThe advent of quantitative phosphoproteomics has brought the field on the doorstep of systems biology, but a number of challenges remain before the bacterial phosphorylation networks can be efficiently modeled and their physiological role understood. This article is part of a Special Issue entitled: Systems Biology of Microorganisms.
Original languageEnglish
JournalB B A - General Subjects
Volume1810
Issue number10
Pages (from-to)989-994
ISSN0304-4165
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Protein phosphorylation
  • Protein kinase
  • Phosphoproteomics
  • Phosphorylation predictor
  • Signal transduction

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