Protein feature based identification of cell cycle regulated proteins in yeast

Ulrik de Lichtenberg, Thomas Skøt Jensen, Lars Juhl Jensen, Søren Brunak

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    DNA microarrays have been used extensively to identify cell cycle regulated genes in yeast; however, the overlap in the genes identified is surprisingly small. We show that certain protein features can be used to distinguish cell cycle regulated genes from other genes with high confidence (features include protein phosphorylation, glycosylation, subcellular location and instability/degradation). We demonstrate that co-expressed, periodic genes encode proteins which share combinations of features, and provide an overview of the proteome dynamics during the cycle. A large set of novel putative cell cycle regulated proteins were identified, many of which have no known function.
    Original languageEnglish
    JournalJournal of molecular biology
    Volume329
    Issue number4
    Pages (from-to)663-674
    ISSN0022-2836
    Publication statusPublished - 2003

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