Abstract
Materials for insulin containers and delivery systems should comply with requirements
like compatibility with proteins, sterilisability, 'good barrier properties towards
preservatives, and no toxic leachables. The number of commercially available polymer
materials which can be u
sed is rather limited. Therefore, a polymer coating containing some of the required
properties may expand the use ofpolymers in medical devices.
'The approach was to graft polymer brushes from initiator-functionalized substrates using
Surface-Initiated Atom TnlJlsfer Radical Polymerization (SI ATRP). Initial studies have
been made with model systems of poly(ether ether ketone) (PEEK) films as they can
easily be functionalized [1]. Moreover, the inert material polypropylene has successfully
beel! activated using a photochemical method [2]. Different polymers including PEG-like
matenals have been investigated as coating materials. ATR FTIR, water contact angle
measurements, Thermal Gravimetric Analysis (TGA), and X-ray Photoelectron
Spectroscopy (XPS) confirmed that hydrophilic polymers have been grafted from the
surface. The surface topography which was evaluated by Atomic Force Microscopy
(AFM) did not change when the PEEK films were modified. The surface roughness
should either be unchanged or decreased as it 'will affect the protein adsorption [3].
1. O. Noiset, C. Henneuse, Y.-J. Schneider, J. Marchand-Brynaert Macromolecules 30
(1997) 540-548
2. J. Huang, H. Murata, R.R. Koepsel, A.J. Russell, K. Matyjaszewski
Biomacromolecules 8 (2007) 1396-1399
3. A.F. von Recum, T.~~. van KootenJ Biomat Sci-Polym E 7 (1995) 181-198.
Original language | English |
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Title of host publication | NPD Nordic Polymer Days 2008 |
Number of pages | 71 |
Publication date | 2008 |
Publication status | Published - 2008 |
Event | Nordic Polymer Days 2008 - Stockholm, Sweden Duration: 11 Jun 2008 → 13 Jun 2008 |
Conference
Conference | Nordic Polymer Days 2008 |
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Country | Sweden |
City | Stockholm |
Period | 11/06/2008 → 13/06/2008 |