TY - JOUR
T1 - Protein annotation in the era of personal genomics
AU - Holberg Blicher, Thomas
AU - Gupta, Ramneek
AU - Wesolowska, Agata
AU - Jensen, Lars Juhl
AU - Brunak, Søren
PY - 2010
Y1 - 2010
N2 - Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular-the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health. Copyright © 2010 Elsevier Ltd. All rights reserved.
AB - Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular-the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health. Copyright © 2010 Elsevier Ltd. All rights reserved.
U2 - 10.1016/j.sbi.2010.03.008
DO - 10.1016/j.sbi.2010.03.008
M3 - Journal article
C2 - 20403684
SN - 0959-440X
VL - 20
SP - 335
EP - 341
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 3
ER -