Protein annotation in the era of personal genomics

Thomas Holberg Blicher, Ramneek Gupta, Agata Wesolowska, Lars Juhl Jensen, Søren Brunak

    Research output: Contribution to journalJournal articlepeer-review


    Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular-the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health. Copyright © 2010 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    JournalCurrent Opinion in Structural Biology
    Issue number3
    Pages (from-to)335-341
    Publication statusPublished - 2010


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