Protective role of complement C3 against cytokine-mediated beta cell apoptosis

R. S. Dos Santos; L. Marroqui; F. A. Grieco; L. Marselli; S. R. Henz; P. Marchetti; Rasmus Wernersson; D. L. Eizirik

Protective role of complement C3 against cytokine-mediated beta cell apoptosis

R. S. Dos Santos, L. Marroqui, F. A. Grieco, L. Marselli, S. R. Henz, P. Marchetti, Rasmus Wernersson, D. L. Eizirik

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

Abstract

Background and aims: Type 1 diabetes is a chronic autoimmune disease characterized by pancreatic islet inflammation and β-cell destruction by pro-inflammatory cytokines and other mediators. The complement system, a major component of the immune system, has been recently shown to also act in metabolic organs, such as liver, adipose tissue, and pancreas. In the present study we identified complement C3 as an important hub of a cytokine-modified complement network in human islets and characterized the role of C3 in β-cell survival.

Original language	English
Article number	433
Journal	Diabetologia
Volume	60
Issue number	Suppl. 1
Pages (from-to)	S198
ISSN	0012-186X
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

OpenUrl availability

Full text

Cite this

@article{e5e88897c9bb4f9c81e0c773e94b8d86,

title = "Protective role of complement C3 against cytokine-mediated beta cell apoptosis",

abstract = "Background and aims: Type 1 diabetes is a chronic autoimmune disease characterized by pancreatic islet inflammation and β-cell destruction by pro-inflammatory cytokines and other mediators. The complement system, a major component of the immune system, has been recently shown to also act in metabolic organs, such as liver, adipose tissue, and pancreas. In the present study we identified complement C3 as an important hub of a cytokine-modified complement network in human islets and characterized the role of C3 in β-cell survival.",

author = "{Dos Santos}, {R. S.} and L. Marroqui and Grieco, {F. A.} and L. Marselli and Henz, {S. R.} and P. Marchetti and Rasmus Wernersson and Eizirik, {D. L.}",

year = "2017",

language = "English",

volume = "60",

pages = "S198",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "Suppl. 1",

}

TY - ABST

T1 - Protective role of complement C3 against cytokine-mediated beta cell apoptosis

AU - Dos Santos, R. S.

AU - Marroqui, L.

AU - Grieco, F. A.

AU - Marselli, L.

AU - Henz, S. R.

AU - Marchetti, P.

AU - Wernersson, Rasmus

AU - Eizirik, D. L.

PY - 2017

Y1 - 2017

N2 - Background and aims: Type 1 diabetes is a chronic autoimmune disease characterized by pancreatic islet inflammation and β-cell destruction by pro-inflammatory cytokines and other mediators. The complement system, a major component of the immune system, has been recently shown to also act in metabolic organs, such as liver, adipose tissue, and pancreas. In the present study we identified complement C3 as an important hub of a cytokine-modified complement network in human islets and characterized the role of C3 in β-cell survival.

AB - Background and aims: Type 1 diabetes is a chronic autoimmune disease characterized by pancreatic islet inflammation and β-cell destruction by pro-inflammatory cytokines and other mediators. The complement system, a major component of the immune system, has been recently shown to also act in metabolic organs, such as liver, adipose tissue, and pancreas. In the present study we identified complement C3 as an important hub of a cytokine-modified complement network in human islets and characterized the role of C3 in β-cell survival.

M3 - Conference abstract in journal

SN - 0012-186X

VL - 60

SP - S198

JO - Diabetologia

JF - Diabetologia

IS - Suppl. 1

M1 - 433

ER -

Protective role of complement C3 against cytokine-mediated beta cell apoptosis

Abstract

UN SDGs

OpenUrl availability

Fingerprint

Cite this