Protective effect of squalene on certain lysosomal hydrolases and free amino acids in isoprenaline-induced myocardial infarction in rats

Sabeena Farvin, A. Surendraraj, R. Anandan

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

This study was aimed to evaluate the preventive role of squalene on free amino acids and lysosomal alterations in experimentally induced myocardial infarction in rats. The levels of lysosomal enzymes (beta-glucuronidase, beta-galactosidase, beta-glucosidase, acid phosphatase and cathepsin D) in plasma and lysosomal fractions, hydroxyproline content and free amino acids in heart tissue were determined. Isoprenaline administration to rats resulted in decreased stability of the membranes which was reflected by significantly (p
Original languageEnglish
JournalInternational Journal of Pharmacology
Volume6
Issue number2
Pages (from-to)97-103
ISSN1811-7775
DOIs
Publication statusPublished - 2010

Keywords

  • arginine
  • hydroxyproline
  • aspartate
  • taurine
  • Lysosomal hydrolases
  • glutamate

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