Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination

S.E. LaPatra; S. Corbeil; G.R. Jones; W.D. Shewmaker; Niels Lorenzen; E.D. Anderson; G. Kurath

doi:10.1016/S0264-410X(01)00113-X

Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination

S.E. LaPatra, S. Corbeil, G.R. Jones, W.D. Shewmaker, Niels Lorenzen, E.D. Anderson, G. Kurath

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was shown to provide significant protection as soon as 4 d after intramuscular vaccination in 2 g rainbow trout (Oncorhynchus mykiss) held at 15 degreesC. Nearly complete protection was also observed at later time points (7, 14, and 28 d) using a standardized waterborne challenge model. In a test of the specificity of this early protection, immunization of rainbow trout with a DNA vaccine against another fish rhabdovirus, viral hemorrhagic septicemia virus, provided a significant level of cross-protection against IHNV challenge for a transient period of time, whereas a rabies virus DNA vaccine was not protective. This indication of distinct early and late protective mechanisms was not dependent on DNA vaccine doses from 0.1 to 2.5 mug.

Original language	English
Journal	Vaccine
Volume	19
Issue number	28-29
Pages (from-to)	4011-4019
ISSN	0264-410X
DOIs	https://doi.org/10.1016/S0264-410X(01)00113-X
Publication status	Published - 2001

Keywords

DNA vaccine kinetics
fish DNA vaccine specificity
viral hemorrhagic septicemia virus (VHSV)
infectious hematopoietic necrosis virus (IHNV)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0264-410X(01)00113-X

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title = "Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination",

abstract = "A DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was shown to provide significant protection as soon as 4 d after intramuscular vaccination in 2 g rainbow trout (Oncorhynchus mykiss) held at 15 degreesC. Nearly complete protection was also observed at later time points (7, 14, and 28 d) using a standardized waterborne challenge model. In a test of the specificity of this early protection, immunization of rainbow trout with a DNA vaccine against another fish rhabdovirus, viral hemorrhagic septicemia virus, provided a significant level of cross-protection against IHNV challenge for a transient period of time, whereas a rabies virus DNA vaccine was not protective. This indication of distinct early and late protective mechanisms was not dependent on DNA vaccine doses from 0.1 to 2.5 mug.",

keywords = "DNA vaccine kinetics, fish DNA vaccine specificity, viral hemorrhagic septicemia virus (VHSV), infectious hematopoietic necrosis virus (IHNV)",

author = "S.E. LaPatra and S. Corbeil and G.R. Jones and W.D. Shewmaker and Niels Lorenzen and E.D. Anderson and G. Kurath",

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T1 - Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination

AU - LaPatra, S.E.

AU - Corbeil, S.

AU - Jones, G.R.

AU - Shewmaker, W.D.

AU - Lorenzen, Niels

AU - Anderson, E.D.

AU - Kurath, G.

PY - 2001

Y1 - 2001

N2 - A DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was shown to provide significant protection as soon as 4 d after intramuscular vaccination in 2 g rainbow trout (Oncorhynchus mykiss) held at 15 degreesC. Nearly complete protection was also observed at later time points (7, 14, and 28 d) using a standardized waterborne challenge model. In a test of the specificity of this early protection, immunization of rainbow trout with a DNA vaccine against another fish rhabdovirus, viral hemorrhagic septicemia virus, provided a significant level of cross-protection against IHNV challenge for a transient period of time, whereas a rabies virus DNA vaccine was not protective. This indication of distinct early and late protective mechanisms was not dependent on DNA vaccine doses from 0.1 to 2.5 mug.

AB - A DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was shown to provide significant protection as soon as 4 d after intramuscular vaccination in 2 g rainbow trout (Oncorhynchus mykiss) held at 15 degreesC. Nearly complete protection was also observed at later time points (7, 14, and 28 d) using a standardized waterborne challenge model. In a test of the specificity of this early protection, immunization of rainbow trout with a DNA vaccine against another fish rhabdovirus, viral hemorrhagic septicemia virus, provided a significant level of cross-protection against IHNV challenge for a transient period of time, whereas a rabies virus DNA vaccine was not protective. This indication of distinct early and late protective mechanisms was not dependent on DNA vaccine doses from 0.1 to 2.5 mug.

KW - DNA vaccine kinetics

KW - fish DNA vaccine specificity

KW - viral hemorrhagic septicemia virus (VHSV)

KW - infectious hematopoietic necrosis virus (IHNV)

U2 - 10.1016/S0264-410X(01)00113-X

DO - 10.1016/S0264-410X(01)00113-X

M3 - Journal article

SN - 0264-410X

VL - 19

SP - 4011

EP - 4019

JO - Vaccine

JF - Vaccine

IS - 28-29

ER -

Protection of rainbow trout against infectious hematopoietic necrosis virus four days after specific or semi-specific DNA vaccination

Abstract

Keywords

UN SDGs

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