PROTACs and HyT-PD molecules for targeted protein degradation of dcaf15 and their use in the treatment of amyloidosis

Sólveig Hlín Brynjólfsdóttir; Lisa Beth Frankel; Luca Laraia; Joseph Franz Georg Hoock; Maria Brandt Schjønning; Matilde Lind Hartvig Nielsen

PROTACs and HyT-PD molecules for targeted protein degradation of dcaf15 and their use in the treatment of amyloidosis

Sólveig Hlín Brynjólfsdóttir (Inventor)
, Lisa Beth Frankel (Inventor)
, Luca Laraia (Inventor)
, Joseph Franz Georg Hoock (Inventor)
, Maria Brandt Schjønning (Inventor)
, Matilde Lind Hartvig Nielsen (Inventor)

Research output: Patent

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Abstract

The present invention relates to the finding of the role of DCAF15 in protein aggregation. The present invention further relates to PROTACs and HyT-PD molecules for targeted protein degradation (TPD) of DCAF15 as well as their use as a medicament for the treatment of amyloidosis, in particular their use in the treatment of synucleinopathies.

Original language	English
IPC	C07D 333/ 10 A I
Patent number	WO2024251876
Filing date	06/06/2024
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	19/01/2024
Priority number	EP20240152991
Publication status	Published - 2024

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title = "PROTACs and HyT-PD molecules for targeted protein degradation of dcaf15 and their use in the treatment of amyloidosis",

abstract = "The present invention relates to the finding of the role of DCAF15 in protein aggregation. The present invention further relates to PROTACs and HyT-PD molecules for targeted protein degradation (TPD) of DCAF15 as well as their use as a medicament for the treatment of amyloidosis, in particular their use in the treatment of synucleinopathies.",

author = "Brynj{\'o}lfsd{\'o}ttir, \{S{\'o}lveig Hl{\'i}n\} and Frankel, \{Lisa Beth\} and Luca Laraia and Hoock, \{Joseph Franz Georg\} and Schj{\o}nning, \{Maria Brandt\} and Nielsen, \{Matilde Lind Hartvig\}",

year = "2024",

language = "English",

type = "Patent",

note = "WO2024251876; C07D 333/ 10 A I",

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TY - PAT

T1 - PROTACs and HyT-PD molecules for targeted protein degradation of dcaf15 and their use in the treatment of amyloidosis

AU - Brynjólfsdóttir, Sólveig Hlín

AU - Frankel, Lisa Beth

AU - Laraia, Luca

AU - Hoock, Joseph Franz Georg

AU - Schjønning, Maria Brandt

AU - Nielsen, Matilde Lind Hartvig

PY - 2024

Y1 - 2024

N2 - The present invention relates to the finding of the role of DCAF15 in protein aggregation. The present invention further relates to PROTACs and HyT-PD molecules for targeted protein degradation (TPD) of DCAF15 as well as their use as a medicament for the treatment of amyloidosis, in particular their use in the treatment of synucleinopathies.

AB - The present invention relates to the finding of the role of DCAF15 in protein aggregation. The present invention further relates to PROTACs and HyT-PD molecules for targeted protein degradation (TPD) of DCAF15 as well as their use as a medicament for the treatment of amyloidosis, in particular their use in the treatment of synucleinopathies.

M3 - Patent

M1 - WO2024251876

Y2 - 2024/06/06

ER -

PROTACs and HyT-PD molecules for targeted protein degradation of dcaf15 and their use in the treatment of amyloidosis

Abstract

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