Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties

Palle Jacob Pedersen, Sidsel K. Adolph, Thomas Lars Andresen, Mogens W. Madsen, Robert Madsen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articleResearchpeer-review


The synthesis of two secretory phospholipase A(2) IIA sensitive 15-deoxy-Delta(12,14)-prostaglandin J(2) phospholipid conjugates is described and their biophysical and biological properties are reported. The conjugates spontaneously form particles in the liposome size region upon dispersion in an aqueous buffer and both phospholipids are hydrolyzed by phospholipase A(2), but with different conversion rates and extent of hydrolysis. The cytotoxicity was evaluated in HT-29 and Colo205 cells and the conjugates induced cell death in the presence of phospholipase A(2) and surprisingly also in the absence of the enzyme.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Issue number15
Pages (from-to)4456-4458
Publication statusPublished - 2010


  • Drug delivery
  • Prostaglandins
  • Phospholipds
  • Liposomes


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