Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties

Palle Jacob Pedersen, Sidsel K. Adolph, Thomas Lars Andresen, Mogens W. Madsen, Robert Madsen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The synthesis of two secretory phospholipase A(2) IIA sensitive 15-deoxy-Delta(12,14)-prostaglandin J(2) phospholipid conjugates is described and their biophysical and biological properties are reported. The conjugates spontaneously form particles in the liposome size region upon dispersion in an aqueous buffer and both phospholipids are hydrolyzed by phospholipase A(2), but with different conversion rates and extent of hydrolysis. The cytotoxicity was evaluated in HT-29 and Colo205 cells and the conjugates induced cell death in the presence of phospholipase A(2) and surprisingly also in the absence of the enzyme.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume20
Issue number15
Pages (from-to)4456-4458
ISSN0960-894X
DOIs
Publication statusPublished - 2010

Keywords

  • Drug delivery
  • Prostaglandins
  • Phospholipds
  • Liposomes

Fingerprint Dive into the research topics of 'Prostaglandin phospholipid conjugates with unusual biophysical and cytotoxic properties'. Together they form a unique fingerprint.

Cite this