Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

Angela B Seddon; Bruce Napier; Ian Lindsay; Samir Lamrini; Peter M. Moselund; Nicholas Stone; Ole Bang; Mark Farries

doi:10.1039/c8an01396a

Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

Angela B Seddon^*
, Bruce Napier
, Ian Lindsay
, Samir Lamrini
, Peter M. Moselund
, Nicholas Stone
, Ole Bang
, Mark Farries

^*Corresponding author for this work

University of Nottingham
Vivid Components Ltd.
University of Bristol
LISA Laser Products
NKT Photonics A/S
University of Exeter
Gooch and Housego Ltd.

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Abstract

Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral 'fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a 'few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the 'fingerprint region'.

Original language	English
Journal	Analyst
Volume	143
Issue number	24
Pages (from-to)	5874-5887
ISSN	0003-2654
DOIs	https://doi.org/10.1039/c8an01396a
Publication status	Published - 2018

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SDG 3 Good Health and Well-being

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title = "Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease",

abstract = "Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral 'fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a 'few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the 'fingerprint region'.",

author = "Seddon, \{Angela B\} and Bruce Napier and Ian Lindsay and Samir Lamrini and Moselund, \{Peter M.\} and Nicholas Stone and Ole Bang and Mark Farries",

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doi = "10.1039/c8an01396a",

language = "English",

volume = "143",

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T1 - Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

AU - Seddon, Angela B

AU - Napier, Bruce

AU - Lindsay, Ian

AU - Lamrini, Samir

AU - Moselund, Peter M.

AU - Stone, Nicholas

AU - Bang, Ole

AU - Farries, Mark

PY - 2018

Y1 - 2018

N2 - Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral 'fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a 'few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the 'fingerprint region'.

AB - Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer. Recently, we reported for the first time an optical fibre based broadband supercontinuum (SC) laser source spanning 1.3 to 13.4 μm wavelength to cover the spectral 'fingerprint region' of biological tissue. This work has catalysed the new field of fibre MIR-SC and now very bright sources equivalent to a 'few synchrotrons' have been demonstrated in fibre. In addition, we have made record transparency MIR fibre for routeing the MIR light and reported first-time MIR photoluminescence (with long lifetime) in small-core, rare earth ion doped, MIR fibre - an important step towards MIR fibre lasing at >4 μm wavelength for pumping fibre MIR-SC. First time fibre MIR-SC spectroscopic imaging of colon tissue is described at wavelengths in the 'fingerprint region'.

U2 - 10.1039/c8an01396a

DO - 10.1039/c8an01396a

M3 - Journal article

C2 - 30475355

SN - 0003-2654

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EP - 5887

JO - Analyst

JF - Analyst

IS - 24

ER -

Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease

Abstract

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