Abstract
Antibody technologies are
being increasingly applied in the field of toxinology. Fuelled by the many
advances in immunology, synthetic biology, and antibody research, different
approaches and antibody formats are being investigated for the ability to
neutralize animal toxins. These different molecular formats each have their own
therapeutic characteristics. In this review, we provide an overview of the
advances made in the development of toxin-targeting antibodies, and discuss the
benefits and drawbacks of different antibody formats in relation to their
ability to neutralize toxins, pharmacokinetic features, propensity to cause
adverse reactions, formulation, and expression for research and development
(R&D) purposes and large-scale manufacturing. A research trend seems to be
emerging towards the use of human antibody formats as well as camelid
heavy-domain antibody fragments due to their compatibility with the human
immune system, beneficial therapeutic properties, and the ability to
manufacture these molecules cost-effectively.
Original language | English |
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Journal | Toxicon |
Volume | 146 |
Pages (from-to) | 151-175 |
ISSN | 0041-0101 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- Antivenom
- Venom
- Recombinant antivenom
- Antibodies
- Snakebite
- Scorpion sting
- Spider bite
- Animal envenoming
- Pharmacokinetics
- Pharmacodynamics
- Immunogenicity
- Venom neutralization
- Antibody expression
- Antivenom design
- Adverse reactions
- Neglected tropical diseases
- Biotechnology