Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.

Helene Marie-France Viart; T. S. Larsen; Chiara Tassone; Thomas Lars Andresen; Mads Hartvig Clausen

doi:10.1039/c4cc00863d

Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.

Helene Marie-France Viart
, T. S. Larsen
, Chiara Tassone
, Thomas Lars Andresen
, Mads Hartvig Clausen

Technical University of Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.

Original language	English
Journal	Chemical Communications
Volume	50
Issue number	58
Pages (from-to)	7800-7802
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c4cc00863d
Publication status	Published - 2014

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title = "Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.",

abstract = "A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.",

author = "Viart, \{Helene Marie-France\} and Larsen, \{T. S.\} and Chiara Tassone and Andresen, \{Thomas Lars\} and Clausen, \{Mads Hartvig\}",

year = "2014",

doi = "10.1039/c4cc00863d",

language = "English",

volume = "50",

pages = "7800--7802",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.

AU - Viart, Helene Marie-France

AU - Larsen, T. S.

AU - Tassone, Chiara

AU - Andresen, Thomas Lars

AU - Clausen, Mads Hartvig

PY - 2014

Y1 - 2014

N2 - A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.

AB - A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.

U2 - 10.1039/c4cc00863d

DO - 10.1039/c4cc00863d

M3 - Journal article

C2 - 24903342

SN - 1359-7345

VL - 50

SP - 7800

EP - 7802

JO - Chemical Communications

JF - Chemical Communications

IS - 58

ER -

Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.

Abstract

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