Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.

Helene Marie-France Viart, T. S. Larsen, Chiara Tassone, Thomas Lars Andresen, Mads Hartvig Clausen

Research output: Contribution to journalJournal articlepeer-review


A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method.
Original languageEnglish
JournalChemical Communications
Issue number58
Pages (from-to)7800-7802
Publication statusPublished - 2014


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