TY - JOUR
T1 - Progress in self-healing hydrogels and their applications in bone tissue engineering
AU - Erezuma, Itsasne
AU - Lukin, Izeia
AU - Desimone, Martin
AU - Zhang, Yu Shrike
AU - Dolatshahi-Pirouz, Alireza
AU - Orive, Gorka
PY - 2022
Y1 - 2022
N2 - Bone tissue engineering (BTE) is constantly seeking novel treatments to address bone injuries in all their varieties. It is necessary to find new ways to create structures that perfectly emulate the native tissue. Self-healing hydrogels have been a breakthrough in this regard, as they are able to reconstitute their links after they have been partially broken. Among the most outstanding biomaterials when it comes to developing these hydrogels for BTE, those polymers of natural origin (e.g., gelatin, alginate) stand out, although synthetics such as PEG or nanomaterials like laponite are also key for this purpose. Self-healing hydrogels have proven to be efficient in healing bone, but have also played a key role as delivery-platforms for drugs or other biological agents. Moreover, some researchers have identified novel uses for these gels as bone fixators or implant coatings. Here, we review the progress of self-healing hydrogels, which hold great promise in the field of tissue engineering.
AB - Bone tissue engineering (BTE) is constantly seeking novel treatments to address bone injuries in all their varieties. It is necessary to find new ways to create structures that perfectly emulate the native tissue. Self-healing hydrogels have been a breakthrough in this regard, as they are able to reconstitute their links after they have been partially broken. Among the most outstanding biomaterials when it comes to developing these hydrogels for BTE, those polymers of natural origin (e.g., gelatin, alginate) stand out, although synthetics such as PEG or nanomaterials like laponite are also key for this purpose. Self-healing hydrogels have proven to be efficient in healing bone, but have also played a key role as delivery-platforms for drugs or other biological agents. Moreover, some researchers have identified novel uses for these gels as bone fixators or implant coatings. Here, we review the progress of self-healing hydrogels, which hold great promise in the field of tissue engineering.
KW - Biomaterials
KW - Bone tissue engineering
KW - Hydrogel
KW - Self-healing
U2 - 10.1016/j.bioadv.2022.213274
DO - 10.1016/j.bioadv.2022.213274
M3 - Review
C2 - 36640523
SN - 2772-9508
VL - 146
JO - Biomaterials Advances
JF - Biomaterials Advances
M1 - 213274
ER -