Programmed survival of soil bacteria

Lars Bogø Jensen, Søren Molin, Claus Sternberg, J.L. Ramos

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Biological containment systems have been developed for Pseudomonas putida
and related soil bacteria. The systems are based on combinations of lethal genes
and regulated gene expression. Two types of killing function have been
employed: 1) A membrane protein interfering with the membrane potential (geJ).
and 2) a nuclease attacking nucleic acids intracellularly. The efficacy of these
lethal genes has been assessed in model constructions with a synthetic lac promoter.
By combination with the regulatory pathway of the TOL genes. a system
was designed which allows bacterial growth in the presence of aromatics but
results in suicide after degradation of the compound. TIme dependent induction of
suicide is under conslrUction.
Original languageEnglish
Publication date1992
Number of pages4
Publication statusPublished - 1992
Event6th International Symposium on Microbial Ecology - Barcelona, Spain
Duration: 6 Sep 199211 Sep 1992
Conference number: 6


Conference6th International Symposium on Microbial Ecology


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