TY - JOUR
T1 - Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast
AU - Jakočiūnas, Tadas
AU - Klitgaard, Andreas K.
AU - Kontou, Eftychia Eva
AU - Nielsen, Julie Bang
AU - Thomsen, Emil
AU - Romero Suarez, David
AU - Blin, Kai
AU - Petzold, Christopher J.
AU - Gin, Jennifer W.
AU - Tong, Yaojun
AU - Gotfredsen, Charlotte Held
AU - Charusanti, Pep
AU - Frandsen, Rasmus J. N.
AU - Weber, Tilmann
AU - Lee, Sang Yup
AU - Jensen, Michael Krogh
AU - Keasling, Jay D.
PY - 2020
Y1 - 2020
N2 - To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host.
AB - To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host.
KW - Natural productions
KW - Synthetic biology
KW - Aromatic polyketides
KW - CRISPR/Cas9
KW - Polyketide
KW - Production platform in eukaryotes
KW - Metabolic engineering
KW - Biotechnology
U2 - 10.1016/j.synbio.2020.01.004
DO - 10.1016/j.synbio.2020.01.004
M3 - Journal article
C2 - 32021916
SN - 2405-805x
VL - 5
SP - 11
EP - 18
JO - Synthetic and Systems Biotechnology
JF - Synthetic and Systems Biotechnology
IS - 1
ER -