Abstract

To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host.
Original languageEnglish
JournalSynthetic and Systems Biotechnology
Volume5
Issue number1
Pages (from-to)11-18
Number of pages8
ISSN2405-805x
DOIs
Publication statusPublished - 2020

Keywords

  • Natural productions
  • Synthetic biology
  • Aromatic polyketides
  • CRISPR/Cas9
  • Polyketide
  • Production platform in eukaryotes
  • Metabolic engineering
  • Biotechnology

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