Production of n-glycoproteins for enzyme assisted glycomodification

Shamim Herbert Rahmann; Carsten Behrens; Malene Bech Vester-Christensen; Henrik Clausen; Yang Zhang; Adnan Fevzi Halim; Eric Bennett

Production of n-glycoproteins for enzyme assisted glycomodification

Shamim Herbert Rahmann (Inventor), Carsten Behrens (Inventor), Malene Bech Vester-Christensen (Inventor), Henrik Clausen (Inventor), Yang Zhang (Inventor), Adnan Fevzi Halim (Inventor), Eric Bennett (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprisingone or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.

Original language	English
IPC	C12N 15/ 90 A I
Patent number	WO2017008982
Filing date	19/01/2017
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	16/07/2015
Priority number	US201562193433P
Publication status	Published - 19 Jan 2017

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abstract = "The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprisingone or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.",

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AU - Herbert Rahmann, Shamim

AU - Behrens, Carsten

AU - Vester-Christensen, Malene Bech

AU - Clausen, Henrik

AU - Zhang, Yang

AU - Halim, Adnan Fevzi

AU - Bennett, Eric

PY - 2017/1/19

Y1 - 2017/1/19

N2 - The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprisingone or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.

AB - The present invention relates to a cell comprising a gene encoding a polypeptide of interest, wherein the polypeptide of interest is expressed comprisingone or more posttranslational modification patterns. These modifications are useful for example in improvement of pharmacokinetic properties, i.e. by attaching PEG chains to proteins. The present invention also relates to methods for producing the antibodies and compositions comprising the antibodies, and their uses.

M3 - Patent

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Y2 - 2017/01/19

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Production of n-glycoproteins for enzyme assisted glycomodification

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