TY - JOUR
T1 - Production and Ex Vivo Characterization of Melting Lipid Needle Patches Applied for Transdermal Delivery of Lipophilic Drugs
AU - Tollemeto, Matteo
AU - Thamdrup, Lasse Ho̷jlund Eklund
AU - Zhang, Zhongyang
AU - Badillo-Ramirez, Isidro
AU - Untracht, Gavrielle R.
AU - Andersen, Peter Eskil
AU - Hagner Nielsen, Line
AU - Boisen, Anja
N1 - Publisher Copyright:
© 2024 American Chemical Society.
PY - 2024
Y1 - 2024
N2 - Microneedle patches have gained significant attention for transdermal drug delivery, particularly those made from hydrophilic polymers for hydrophilic drugs. However, delivering poorly water-soluble lipophilic drugs remains a challenge. Our study introduces a lipid-based microneedle patch capable of effectively delivering lipophilic drugs with mechanically robust needles that penetrate physiological barriers like skin. Using a high-yield melt casting method, we produced needles up to 1200 μm in length with tunable melting points and phase transitions by adjusting lipid compositions. These patches release drugs at body temperature (37 °C). In a proof-of-concept experiment, curcumin, a model lipophilic drug, was fully dissolved and uniformly distributed in the needles, with drug loadings up to 50 wt %. Ex vivo studies demonstrated successful needle penetration and drug release in porcine skin. This lipid-based microneedle platform offers an effective solution for the transdermal, transmucosal, and buccal delivery of lipophilic drugs.
AB - Microneedle patches have gained significant attention for transdermal drug delivery, particularly those made from hydrophilic polymers for hydrophilic drugs. However, delivering poorly water-soluble lipophilic drugs remains a challenge. Our study introduces a lipid-based microneedle patch capable of effectively delivering lipophilic drugs with mechanically robust needles that penetrate physiological barriers like skin. Using a high-yield melt casting method, we produced needles up to 1200 μm in length with tunable melting points and phase transitions by adjusting lipid compositions. These patches release drugs at body temperature (37 °C). In a proof-of-concept experiment, curcumin, a model lipophilic drug, was fully dissolved and uniformly distributed in the needles, with drug loadings up to 50 wt %. Ex vivo studies demonstrated successful needle penetration and drug release in porcine skin. This lipid-based microneedle platform offers an effective solution for the transdermal, transmucosal, and buccal delivery of lipophilic drugs.
U2 - 10.1021/acsmaterialslett.4c01686
DO - 10.1021/acsmaterialslett.4c01686
M3 - Journal article
AN - SCOPUS:85207870569
SN - 2639-4979
VL - 6
SP - 5199
EP - 5207
JO - ACS Materials Letters
JF - ACS Materials Letters
IS - 11
ER -