Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours

Helge Thisgaard; Dennis Ringkjøbing Elema; Mikael Jensen

doi:10.1118/1.3608905

Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours

Helge Thisgaard
, Dennis Ringkjøbing Elema
, Mikael Jensen

Odense University Hospital

Research output: Contribution to journal › Conference article › Research › peer-review

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Abstract

Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.

Original language	English
Journal	Medical Physics
Volume	38
Pages (from-to)	4535-
ISSN	0094-2405
DOIs	https://doi.org/10.1118/1.3608905
Publication status	Published - 2011
Event	23rd Annual Congress of the European Association of Nuclear Medicine - Vienna, Austria Duration: 9 Oct 2010 → 13 Oct 2010 Conference number: 23 http://www.eanm.org/congresses_events/congress_calendar/calendar_detail.php?navId=24&eventId=214&year=2010&month=0

Conference

Conference	23rd Annual Congress of the European Association of Nuclear Medicine
Number	23
Country/Territory	Austria
City	Vienna
Period	09/10/2010 → 13/10/2010
Internet address	http://www.eanm.org/congresses_events/congress_calendar/calendar_detail.php?navId=24&eventId=214&year=2010&month=0

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biological tissues
Dosimetry
Impurities
Cellular biophysics
Patient treatment
Cancer
Biomedical materials
Ground states
Cobalt
Radionuclide therapy
Radioisotopes
Auger electrons
Cyclotrons
Pharmaceuticals
Tumours
Co-58m

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@inproceedings{2ba7be555151405ab9ebe65adda81a82,

title = "Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours",

abstract = "Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a b{\th}- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.",

keywords = "Biological tissues, Dosimetry, Impurities, Cellular biophysics, Patient treatment, Cancer, Biomedical materials, Ground states, Cobalt, Radionuclide therapy, Radioisotopes, Auger electrons, Cyclotrons, Pharmaceuticals, Tumours, Co-58m",

author = "Helge Thisgaard and Elema, \{Dennis Ringkj{\o}bing\} and Mikael Jensen",

year = "2011",

doi = "10.1118/1.3608905",

language = "English",

volume = "38",

pages = "4535--",

journal = "Medical Physics",

issn = "0094-2405",

publisher = "John Wiley and Sons Ltd",

note = "23rd Annual Congress of the European Association of Nuclear Medicine, EANM'10 ; Conference date: 09-10-2010 Through 13-10-2010",

url = "http://www.eanm.org/congresses\_events/congress\_calendar/calendar\_detail.php?navId=24\&eventId=214\&year=2010\&month=0",

}

TY - GEN

T1 - Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours

AU - Thisgaard, Helge

AU - Elema, Dennis Ringkjøbing

AU - Jensen, Mikael

N1 - Conference code: 23

PY - 2011

Y1 - 2011

N2 - Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.

AB - Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.

KW - Biological tissues

KW - Dosimetry

KW - Impurities

KW - Cellular biophysics

KW - Patient treatment

KW - Cancer

KW - Biomedical materials

KW - Ground states

KW - Cobalt

KW - Radionuclide therapy

KW - Radioisotopes

KW - Auger electrons

KW - Cyclotrons

KW - Pharmaceuticals

KW - Tumours

KW - Co-58m

U2 - 10.1118/1.3608905

DO - 10.1118/1.3608905

M3 - Conference article

C2 - 21928624

SN - 0094-2405

VL - 38

SP - 4535-

JO - Medical Physics

JF - Medical Physics

T2 - 23rd Annual Congress of the European Association of Nuclear Medicine

Y2 - 9 October 2010 through 13 October 2010

ER -

Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours

Abstract

Conference

UN SDGs

Keywords

Access to Document

OpenUrl availability

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Cite this