Abstract
| Original language | English |
|---|---|
| Journal | Medical Physics |
| Volume | 38 |
| Pages (from-to) | 4535- |
| ISSN | 0094-2405 |
| DOIs | |
| Publication status | Published - 2011 |
| Event | 23rd Annual Congress of the European Association of Nuclear Medicine - Vienna, Austria Duration: 9 Oct 2010 → 13 Oct 2010 Conference number: 23 http://www.eanm.org/congresses_events/congress_calendar/calendar_detail.php?navId=24&eventId=214&year=2010&month=0 |
Conference
| Conference | 23rd Annual Congress of the European Association of Nuclear Medicine |
|---|---|
| Number | 23 |
| Country | Austria |
| City | Vienna |
| Period | 09/10/2010 → 13/10/2010 |
| Internet address |
Keywords
- Biological tissues
- Dosimetry
- Impurities
- Cellular biophysics
- Patient treatment
- Cancer
- Biomedical materials
- Ground states
- Cobalt
- Radionuclide therapy
- Radioisotopes
- Auger electrons
- Cyclotrons
- Pharmaceuticals
- Tumours
- Co-58m
Cite this
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Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours. / Thisgaard, Helge; Elema, Dennis Ringkjøbing; Jensen, Mikael.
In: Medical Physics, Vol. 38, 2011, p. 4535-.Research output: Contribution to journal › Conference article › Research › peer-review
TY - GEN
T1 - Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours
AU - Thisgaard, Helge
AU - Elema, Dennis Ringkjøbing
AU - Jensen, Mikael
PY - 2011
Y1 - 2011
N2 - Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.
AB - Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.
KW - Biological tissues
KW - Dosimetry
KW - Impurities
KW - Cellular biophysics
KW - Patient treatment
KW - Cancer
KW - Biomedical materials
KW - Ground states
KW - Cobalt
KW - Radionuclide therapy
KW - Radioisotopes
KW - Auger electrons
KW - Cyclotrons
KW - Pharmaceuticals
KW - Tumours
KW - Co-58m
U2 - 10.1118/1.3608905
DO - 10.1118/1.3608905
M3 - Conference article
VL - 38
SP - 4535-
JO - Medical Physics
JF - Medical Physics
SN - 0094-2405
ER -