Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours

Helge Thisgaard, Dennis Ringkjøbing Elema, Mikael Jensen

    Research output: Contribution to journalConference articleResearchpeer-review

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    Abstract

    Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.
    Original languageEnglish
    JournalMedical Physics
    Volume38
    Pages (from-to)4535-
    ISSN0094-2405
    DOIs
    Publication statusPublished - 2011
    Event23rd Annual Congress of the European Association of Nuclear Medicine - Vienna, Austria
    Duration: 9 Oct 201013 Oct 2010
    Conference number: 23
    http://www.eanm.org/congresses_events/congress_calendar/calendar_detail.php?navId=24&eventId=214&year=2010&month=0

    Conference

    Conference23rd Annual Congress of the European Association of Nuclear Medicine
    Number23
    CountryAustria
    CityVienna
    Period09/10/201013/10/2010
    Internet address

    Keywords

    • Biological tissues
    • Dosimetry
    • Impurities
    • Cellular biophysics
    • Patient treatment
    • Cancer
    • Biomedical materials
    • Ground states
    • Cobalt
    • Radionuclide therapy
    • Radioisotopes
    • Auger electrons
    • Cyclotrons
    • Pharmaceuticals
    • Tumours
    • Co-58m

    Cite this

    @inproceedings{2ba7be555151405ab9ebe65adda81a82,
    title = "Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours",
    abstract = "Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a b{\th}- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.",
    keywords = "Biological tissues, Dosimetry, Impurities, Cellular biophysics, Patient treatment, Cancer, Biomedical materials, Ground states, Cobalt, Radionuclide therapy, Radioisotopes, Auger electrons, Cyclotrons, Pharmaceuticals, Tumours, Co-58m",
    author = "Helge Thisgaard and Elema, {Dennis Ringkj{\o}bing} and Mikael Jensen",
    year = "2011",
    doi = "10.1118/1.3608905",
    language = "English",
    volume = "38",
    pages = "4535--",
    journal = "Medical Physics",
    issn = "0094-2405",
    publisher = "John Wiley and Sons Inc.",

    }

    Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours. / Thisgaard, Helge; Elema, Dennis Ringkjøbing; Jensen, Mikael.

    In: Medical Physics, Vol. 38, 2011, p. 4535-.

    Research output: Contribution to journalConference articleResearchpeer-review

    TY - GEN

    T1 - Production and dosimetric aspects of the potent Auger emitter Co-58m for targeted radionuclide therapy of small tumours

    AU - Thisgaard, Helge

    AU - Elema, Dennis Ringkjøbing

    AU - Jensen, Mikael

    PY - 2011

    Y1 - 2011

    N2 - Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.

    AB - Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting impurity should be included in the dosimetric analysis. The purpose of this study was to investigate this critical part of dosimetry based on experimentally determined production yields of 58mCo and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated and are presented here for the first time.

    KW - Biological tissues

    KW - Dosimetry

    KW - Impurities

    KW - Cellular biophysics

    KW - Patient treatment

    KW - Cancer

    KW - Biomedical materials

    KW - Ground states

    KW - Cobalt

    KW - Radionuclide therapy

    KW - Radioisotopes

    KW - Auger electrons

    KW - Cyclotrons

    KW - Pharmaceuticals

    KW - Tumours

    KW - Co-58m

    U2 - 10.1118/1.3608905

    DO - 10.1118/1.3608905

    M3 - Conference article

    VL - 38

    SP - 4535-

    JO - Medical Physics

    JF - Medical Physics

    SN - 0094-2405

    ER -