Abstract
Based on theoretical calculations, the Auger emitter 58mCo has been identified as a potent
nuclide for targeted radionuclide therapy of small tumors. During the production of this isotope, the
coproduction of the long-lived ground state 58gCo is unfortunately unavoidable, as is ingrowth of
the ground state following the isomeric decay of 58mCo. The impact of 58gCo as a bþ- and c-emitting
impurity should be included in the dosimetric analysis. The purpose of this study was to investigate
this critical part of dosimetry based on experimentally determined production yields of 58mCo
and 58gCo using a low-energy cyclotron. Also, the cellular S-values for 58mCo have been calculated
and are presented here for the first time.
| Original language | English |
|---|---|
| Journal | Medical Physics |
| Volume | 38 |
| Pages (from-to) | 4535- |
| ISSN | 0094-2405 |
| DOIs | |
| Publication status | Published - 2011 |
| Event | 23rd Annual Congress of the European Association of Nuclear Medicine - Vienna, Austria Duration: 9 Oct 2010 → 13 Oct 2010 Conference number: 23 http://www.eanm.org/congresses_events/congress_calendar/calendar_detail.php?navId=24&eventId=214&year=2010&month=0 |
Conference
| Conference | 23rd Annual Congress of the European Association of Nuclear Medicine |
|---|---|
| Number | 23 |
| Country/Territory | Austria |
| City | Vienna |
| Period | 09/10/2010 → 13/10/2010 |
| Internet address |
Keywords
- Biological tissues
- Dosimetry
- Impurities
- Cellular biophysics
- Patient treatment
- Cancer
- Biomedical materials
- Ground states
- Cobalt
- Radionuclide therapy
- Radioisotopes
- Auger electrons
- Cyclotrons
- Pharmaceuticals
- Tumours
- Co-58m
