Process for the Manufacture of Ajoene Derivatives

Thomas Ostenfeld Larsen (Inventor), Michael Christian Givskov (Inventor), Thomas Bjarnsholt (Inventor), Tim Holm Jakobsen (Inventor), Louise Dahl Christensen (Inventor), Meenakshi Sundaram Shanmugham (Inventor), Richard Kerry Phipps (Inventor), David Ackland Tanner (Inventor), Niels Høiby (Inventor), Peter Østrup Jensen (Inventor)

Research output: Patent

Abstract

The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
Original languageEnglish
IPCA61K31/105
Patent numberWO2012076016
Filing date14/06/2012
CountryDenmark
Publication statusPublished - 2012

Bibliographical note

DTU reference nummer: 92352-08

Cite this

Larsen, T. O., Givskov, M. C., Bjarnsholt, T., Jakobsen, T. H., Christensen, L. D., Shanmugham, M. S., Phipps, R. K., Tanner, D. A., Høiby, N., & Jensen, P. Ø. (2012). IPC No. A61K31/105. Process for the Manufacture of Ajoene Derivatives. (Patent No. WO2012076016).