TY - PAT
T1 - Process for the Manufacture of Ajoene Derivatives
AU - Larsen, Thomas Ostenfeld
AU - Givskov, Michael Christian
AU - Bjarnsholt, Thomas
AU - Jakobsen, Tim Holm
AU - Christensen, Louise Dahl
AU - Shanmugham, Meenakshi Sundaram
AU - Phipps, Richard Kerry
AU - Tanner, David Ackland
AU - Høiby, Niels
AU - Jensen, Peter Østrup
N1 - DTU reference nummer: 92352-08
PY - 2012
Y1 - 2012
N2 - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
AB - The present invention relates to the compound (E,Z)-ajoene of formula (1) for use in treatment of bacterial infections. Another aspect of the present invention is a composition comprising (E,Z)-ajoene of formula (1) and at least one antibiotic. Yet another aspect of the invention relates to a method for manufacturing (E,Z) ajoene of formula (1) wherein the conformation of the internal C=C- bond can be either E or Z or a mixture thereof, said method comprising reacting allicin of formula (3) with an acid in the presence of a solvent to provide (E,Z ajoene) of formula (1) as defined above. Yet another aspect of the invention is (E,Z)-ajoene of formula 1 obtainable by the method described above.
M3 - Patent
M1 - WO2012076016
Y2 - 2012/06/14
ER -